Oligonucleotide microarray analysis of strain- and gender-associated gene expression in the human blood fluke, Schistosoma japonicum

Molecular and Cellular Probes
L P MoertelG N Gobert

Abstract

Schistosomiasis is a chronic and debilitating disease caused by blood flukes (digenetic trematodes) of the genus Schistosoma. Schistosomiasis japonica, a zoonosis caused by Schistosoma japonicum, is endemic to the Philippines and China. We utilised a 22,575 feature custom oligonucleotide DNA microarray designed from public domain databases of schistosome-expressed sequence tags to explore differential gene expression between the Philippine (SJP) and Chinese (SJC) strains of S. japonicum, and between male and female S. japonicum. We found that 593, 664 and 426 probes were differentially expressed between the two geographical strains when we compared mix sexed adults, male worms and female worms. Additionally, the study revealed that 1163 male- and 1016 female-associated probes were differentially expressed in SJP whereas 1047 male- and 897 female-associated probes were differentially expressed in SJC. The study greatly expands previously published data of strain and gender-associated differential expression in S. japonicum. Further, these new data provide a stepping stone for understanding the complexities of the biology, sexual differentiation, maturation, and development of human schistosomes, signaling new approaches for iden...Continue Reading

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Citations

Mar 31, 2011·Development, Growth & Differentiation·Christina Piperi, Athanasios G Papavassiliou
Dec 12, 2012·Journal of Parasitology Research·Laila A NahumGuilherme Oliveira
Mar 27, 2009·BMC Genomics·Geoffrey N GobertDonald P McManus
Jun 21, 2007·BMC Genomics·Michael WaisbergNajib M El-Sayed
Nov 11, 2009·PLoS Neglected Tropical Diseases·Marcela G DrummondGlória R Franco
Jan 17, 2012·Molecular and Biochemical Parasitology·Shuai LiuQijun Chen
Jun 9, 2007·The International Journal of Biochemistry & Cell Biology·Malcolm K JonesGeoffrey N Gobert
Nov 14, 2006·Trends in Parasitology·R Alan WilsonAlasdair Ivens
Jun 17, 2008·Acta Tropica·Guilherme OliveiraSergio Verjovski-Almeida
Jul 13, 2007·Experimental Parasitology·Guilherme Oliveira
Jun 20, 2007·Experimental Parasitology·David L WilliamsTimothy P Yoshino
Jun 20, 2007·Experimental Parasitology·Jaap J van HellemondAloysius G M Tielens
May 23, 2007·Experimental Parasitology·Sergio Verjovski-AlmeidaRicardo DeMarco
Jul 8, 2010·Trends in Parasitology·Geoffrey N Gobert
Mar 6, 2007·Trends in Parasitology·Cornelis H HokkeKarl F Hoffmann
Jul 31, 2014·Molecular and Biochemical Parasitology·Geoffrey N GobertDonald P McManus
Sep 12, 2014·PLoS Neglected Tropical Diseases·Evaristus Chibunna MbanefoKenji Hirayama
Jul 28, 2009·Annual Review of Genomics and Human Genetics·Ze-Guang HanZhu Chen
Aug 6, 2013·Journal of Proteome Research·Min ZhangJiaojiao Lin
Sep 9, 2008·Molecular and Biochemical Parasitology·Anthony D AragonCharles Cunningham

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