Oligonucleotides as antivirals: dream or realistic perspective?

Antiviral Research
Arthur Van Aerschot

Abstract

Many reports have been published on antiviral activity of synthetic oligonucleotides, targeted to act either by a true antisense effect or via non-sequence specific interactions. This short review will try to evaluate the current status of the field by focusing on the effects as reported for inhibition of either HSV-1, HCMV or HIV-1. Following an introduction with a historical background and a brief discussion on the different types of constructs and mechanisms of action, the therapeutic potential of antisense oligonucleotides as antivirals, as well as possible pitfalls upon their evaluation will be discussed.

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P C Zamecnik, M L Stephenson
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M L Stephenson, P C Zamecnik
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C C SmithP O Ts'o
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M MatsukuraS Broder
Apr 6, 1995·Nature·A M KriegD M Klinman
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J R WyattD J Ecker
Dec 1, 1996·Antiviral Research·M P SelvamJ S Epstein
Mar 21, 1998·Pharmacology & Therapeutics·B J Dolnick
May 20, 1998·Antiviral Research·A K Field
Apr 29, 1999·Bioorganic & Medicinal Chemistry·J C VerheijenP F Torrence
Feb 5, 2000·Bioorganic & Medicinal Chemistry·Z JiangS Agrawal
May 12, 2000·Biochimica Et Biophysica Acta·S T Crooke
May 12, 2000·Biochimica Et Biophysica Acta·D PraseuthC Hélène
Jan 29, 2002·Nucleic Acids Research·B VerbeureP Herdewijn
Apr 25, 2002·Nucleic Acids Research·Jens KurreckVolker A Erdmann
Sep 27, 2002·Antiviral Research·Neerja KaushikVirendra N Pandey
Mar 9, 2004·Molecular Biotechnology·Peter E Nielsen
Mar 17, 2005·Bioconjugate Chemistry·Longhu ZhouPaul F Torrence
Mar 23, 2005·Virology·András HorváthJanos Aradi
Apr 12, 2005·Microbes and Infection·Florence Colbère-GarapinKarine Labadie
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·Andrew VaillantShibo Jiang

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Citations

Dec 11, 2007·Nature Biotechnology·Joost HaasnootBen Berkhout
Jan 9, 2008·Antimicrobial Agents and Chemotherapy·Anna LuganiniGiorgio Gribaudo
Mar 19, 2014·Journal of Molecular Modeling·Kamil Maláč, Ivan Barvík
Sep 1, 2006·Expert Opinion on Drug Discovery·Tarek Aboul-Fadl
Mar 4, 2009·Journal of Drug Targeting·Alessandra FraternaleMauro Magnani
Oct 27, 2009·Antiviral Research·Erik De Clercq
Apr 28, 2009·International Journal of Antimicrobial Agents·Giorgio BrandiMauro Magnani
Jun 13, 2015·Future Medicinal Chemistry·Koushik ChandraAssaf Friedler
Aug 12, 2009·Antiviral Research·Megan Moerdyk-SchauweckerLing Jin

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