Oligorecurrent prostate cancer limited to lymph nodes: getting our ducks in a row : Nodal oligorecurrent prostate cancer.

World Journal of Urology
Andrei FodorGianluca Ingrosso

Abstract

Oligorecurrent prostate cancer with exclusive nodal involvement represents a common state of disease, amenable to local therapy. New radio-labeled tracers have enriched the possibility of cancer detection and treatment. In this review, we aim to illustrate the main nuclear medicine diagnostic options and the role of radiotherapy in this setting of patients. We performed a PubMed search referring to the PRISMA guidelines to analyze the performance of PSMA- and choline-PET in detecting oligorecurrence limited to lymph nodes, and to review the main studies supporting either ablative stereotactic body radiotherapy or regional lymph node irradiation in this clinical setting. PSMA-PET has shown higher efficacy in the diagnosis of nodal lesions if compared with choline-PET. More specifically, for PSA ≤ 2 ng/ml, the median detection rate of choline-PET ranges from 19.5 to 44.5%, whereas PSMA ranges from 51.5 to 74%. SBRT achieves high local control rates positively affecting progression-free survival (PFS), with androgen deprivation therapy (ADT)-free survival ranging from 25 to 44 months and with low toxicity rates (0-15%). Prophylactic nodal irradiation shows 3-year PFS rates ranging from 62 to 75%, but with a potential higher risk o...Continue Reading

References

Sep 4, 1995·International Journal of Cancer. Journal International Du Cancer·J K TroyerG L Wright
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Catherine A FossMartin G Pomper
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Barbara Alicja Jereczek-FossaRoberto Orecchia
Oct 19, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Hans Christian RischkeCordula Annette Jilg
Oct 25, 2014·World Journal of Urology·B DettiL Livi
Mar 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias EiberMarkus Schwaiger
May 16, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CeciIrene J Virgolini
Sep 26, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Elena IncertiMaria Picchio
Apr 9, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kambiz RahbarHojjat Ahmadzadehfar
May 3, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·P OstG De Meerleer
Jun 10, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Tiziano GrazianiStefano Fanti
Aug 26, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Johannes SchwenckChristian la Fougère
Jul 28, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Louise EmmettPhillip Stricker
Jul 30, 2017·European Urology Focus·Anwar R PadhaniJohann de Bono
Oct 19, 2017·Practical Radiation Oncology·Jaden D EvansBrian J Davis
Dec 13, 2017·Prostate Cancer and Prostatic Diseases·Roger LiBrian F Chapin
Dec 15, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Piet OstGert De Meerleer

❮ Previous
Next ❯

Citations

Nov 11, 2019·World Journal of Urology·Phuoc T Tran, Piet Ost
May 18, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G IngrossoC Aristei
Sep 29, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Luca NicosiaMarta Scorsetti
Jan 13, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J ValeroC Rubio
Jul 2, 2021·Radiation Oncology·Paul RogowskiMinglun Li
Jul 30, 2021·Acta Oncologica·Anita M Werensteijn-HoninghIna M Jürgenliemk-Schulz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica
V VavassoriMarta Scorsetti
Asia-Pacific Journal of Clinical Oncology
Henry Hi YaoFarshad Foroudi
© 2022 Meta ULC. All rights reserved