Oligoribonucleotides with 2'-O-(tert-butyldimethylsilyl) groups

Current Protocols in Nucleic Acid Chemistry
L Bellon

Abstract

The chemical synthesis of oligoribonucleotides on solid support is routinely performed via the phosphoramidite method. However, the additional 2-OH function of the ribofuranosyl sugar requires suitable protection during oligoribonucleotide synthesis. This unit describes methods for 2-OH protection using the TBDMS group.

References

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Citations

May 2, 2013·Nucleic Acids Research·Tomohiro HamasakiTadaaki Ohgi
Aug 28, 2014·Nucleic Acid Therapeutics·Maryam Yahyaee AnzahaeeMasad J Damha
Apr 23, 2008·Current Protocols in Nucleic Acid Chemistry·F E Wincott
Mar 17, 2018·Analytical and Bioanalytical Chemistry·Lorenzo BarontiKatja Petzold
Mar 25, 2011·Biochemical Society Transactions·Marvin H Caruthers
Jan 11, 2020·Beilstein Journal of Nanotechnology·Anna V EpanchintsevaInna A Pyshnaya
Jan 11, 2020·Frontiers in Oncology·Mikhail I ZharkovElena L Chernolovskaya
Feb 10, 2018·Nucleosides, Nucleotides & Nucleic Acids·Ilya S DovydenkoEvgeny K Apartsin

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