Olivary projecting neurons in the nucleus of Darkschewitsch in the cat receive excitatory monosynaptic input from the cerebellar nuclei

Brain Research
C I de Zeeuw, T J Ruigrok

Abstract

The direct projection from the cerebellar nuclei to the inferior olive is GABAergic. In the present study, we investigated the projection from the cerebellar nuclei to the mesodiencephalic junction which is known to provide an excitatory projection to the inferior olive. The mesodiencephalic junction was studied in cat following anterograde transport of wheatgerm agglutinated horseradish peroxidase from the cerebellar nuclei in combination with: (1) retrograde transport of gold-lectin conjugate from the inferior olive; and (2) postembedding GABA-immunocytochemistry. Light microscopic analysis revealed that overlap of the anterograde and retrograde labeling was especially prominent in the nucleus of Darkschewitsch. Electron microscopic examination of this area showed: (1) that many cerebellar terminals made synaptic contacts with neurons that project to the inferior olive; (2) that virtually all cerebellar terminals were non-GABAergic and displayed an excitatory morphology; and (3) olivary projecting neurons were non-GABAergic. It is concluded that the indirect cerebellar projection to the inferior olive via the nucleus of Darkschewitsch is disynaptic and excitatory.

Citations

Nov 5, 1999·Neuroreport·G GiaquintaV Perciavalle
Sep 12, 2000·The Journal of Comparative Neurology·T J Ruigrok, J Voogd
Apr 1, 1995·The European Journal of Neuroscience·T J Ruigrok, J Voogd
Nov 1, 1995·The European Journal of Neuroscience·C I De Zeeuw, A S Berrebi
May 22, 2001·The Anatomical Record·G R Leichnetz
Aug 21, 2014·Frontiers in Neural Circuits·Anders RasmussenGermund Hesslow
Jun 19, 1996·Annals of the New York Academy of Sciences·C I de Zeeuw, A S Berrebi
Nov 28, 2002·The Journal of Comparative Neurology·Fahad SultanPeter Thier
Dec 15, 2005·Network : Computation in Neural Systems·Mehmet Kuntalp
Jul 8, 1996·The Journal of Comparative Neurology·G D KaufmanA A Perachio
Sep 3, 2010·The Cerebellum·Jan VoogdChris I De Zeeuw
Mar 11, 2006·The Cerebellum·Fredrik Bengtsson, Germund Hesslow
Nov 13, 2020·Brain Structure & Function·Gianpaolo Antonio BasileAlberto Cacciola

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