Olive Leaf Extract Improves the Atherogenic Lipid Profile in Rats Fed a High Cholesterol Diet

Phytotherapy Research : PTR
Ercument OlmezA Var

Abstract

Coronary heart disease because of atherosclerosis is still the most common cause of mortality. Elevated levels of low-density lipoprotein and total cholesterol are major risk factors for atherosclerotic cardiovascular disease. The aim of this study was to evaluate the effects of the olive leaf extract on serum lipid profile, early changes of atherosclerosis and endothelium-dependent relaxations in cholesterol-fed rats. For this purpose, rats were fed by 2% cholesterol-enriched or standard chow for 8 weeks. Some rats in each group were also fed orally by olive leaf extract at doses of 50 or 100 mg/kg/day. Atorvastatin at dose of 20 mg/kg of body weight daily was also given as positive control. After 8 weeks, lipid profiles of rat serums were analyzed. Antioxidant enzyme activities (superoxide dismutase and glutathione peroxidase) and degree of lipid peroxidation (malondialdehyde levels) were also measured in the hearts isolated from rats. In addition, expression of adhesion molecules and endothelium-dependent relaxations of isolated thoracic aortas of rats were evaluated. Total cholesterol and LDL-cholesterol levels were found to be increased in cholesterol-fed rats, and both doses of olive leaf extract and atorvastatin signific...Continue Reading

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Citations

May 4, 2016·Phytotherapy Research : PTR·Daniel Martín-VertedorJonathan Delgado-Adámez
Jul 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bandhita SaibandithDaniel M Commane
Jan 7, 2020·Journal of Food Biochemistry·Ahmed A Abd El-MaksoudGustavo M Ambrósio F de Gouveia
Dec 4, 2016·BMC Complementary and Alternative Medicine·Eun Ju ShinJin-Taek Hwang
May 1, 2021·Animals : an Open Access Journal From MDPI·Andrea IanniGiuseppe Martino
Jul 4, 2021·Environmental Science and Pollution Research International·Harith Abdulrhman AhmedThulfiqar Fawwaz Mutar

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