Olive Oil Nutraceuticals in the Prevention and Management of Diabetes: From Molecules to Lifestyle

International Journal of Molecular Sciences
Ahmad AlkhatibJaakko Tuomilehto

Abstract

Lifestyle is the primary prevention of diabetes, especially type-2 diabetes (T2D). Nutritional intake of olive oil (OO), the key Mediterranean diet component has been associated with the prevention and management of many chronic diseases including T2D. Several OO bioactive compounds such as monounsaturated fatty acids, and key biophenols including hydroxytyrosol and oleuropein, have been associated with preventing inflammation and cytokine-induced oxidative damage, glucose lowering, reducing carbohydrate absorption, and increasing insulin sensitivity and related gene expression. However, research into the interaction of OO nutraceuticals with lifestyle components, especially physical activity, is lacking. Promising postprandial effects have been reported when OO or other similar monounsaturated fatty acids were the main dietary fat compared with other diets. Animal studies have shown a potential anabolic effect of oleuropein. Such effects could be further potentiated via exercise, especially strength training, which is an essential exercise prescription for individuals with T2D. There is also an evidence from in vitro, animal, and limited human studies for a dual preventative role of OO biophenols in diabetes and cancer, especi...Continue Reading

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Citations

Jul 25, 2019·Food & Function·María-Carmen López de Las HazasAlberto Dávalos
Mar 23, 2019·International Journal of Molecular Sciences·Tiziana LarussaFrancesco Luzza
Mar 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu-Tang TungWan-Chun Chiu
Dec 27, 2019·World Journal of Stem Cells·Antonio Casado-DíazJosé Manuel Quesada-Gómez
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Jul 1, 2020·International Journal of Molecular Sciences·Adriana R SilvaCassiano F Gonçalves-de-Albuquerque
Feb 13, 2021·Antioxidants·Petr JežekLydie Plecitá-Hlavatá

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