Olive oils modulate fatty acid content and signaling protein expression in apolipoprotein E knockout mice brain.

Lipids
Regina AlemanyValentina Ruiz-Gutierrez

Abstract

Atherosclerosis contributes to disruption of neuronal signaling pathways by producing lipid-dependent modifications of brain plasma membranes, neuroinflammation and oxidative stress. We investigated whether long-term (11 weeks) consumption of refined- (ROO) and pomace- (POO) olive oil modulated the fatty acid composition and the levels of membrane signaling proteins in the brain of apolipoprotein E (apoE) knockout (KO) mice, an animal model of atherosclerosis. Both of these oils are rich in bioactive molecules with anti-inflammatory and antioxidant effects. ROO and POO long-term consumption increased the proportion of monounsaturated fatty acids (MUFAs), particularly of oleic acid, while reducing the level of the saturated fatty acids (SFAs) palmitic and stearic acid. As a result, the MUFA:SFA ratio was higher in apoE KO mice brain fed with ROO and POO. Furthermore, both oils reduced the level of arachidonic and eicosapentaenoic acid, suggesting a decrease in the generation of pro- and anti-inflammatory eicosanoids. Finally, ROO and POO induced an increase in the density of membrane proteins implicated in both the Galphas/PKA and Galphaq/PLCbeta1/PKCalpha signaling pathways. The combined effects of long-term ROO and POO consump...Continue Reading

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Citations

Oct 27, 2015·Molecular Nutrition & Food Research·Satoshi FukumitsuHiroko Isoda
Feb 15, 2013·Nutritional Neuroscience·Ali Reza Khalatbary
Apr 22, 2017·Biochimica Et Biophysica Acta. Biomembranes·Javier S Perona
Mar 5, 2020·Annals of General Psychiatry·Fatemeh FatemiGity Sotoudeh
Apr 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthew G PontifexAnne-Marie Minihane

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