Olivocochlear neurons in the squirrel monkey brainstem

The Journal of Comparative Neurology
G C Thompson, A M Thompson


Centrifugal projections from the brain to the cochlea have been well described in rodents and cats. In order to gain a better understanding of the general mammalian features of this efferent projection system--the olivocochlear (OC) system--we have begun to extend its description to other mammalian orders, particularly primates. This report describes the origin, cellular morphology, and cholinergic nature of OC neurons in squirrel monkey. Olivocochlear neurons were identified after cochlear injection and subsequent retrograde transport of one of the tracers, horseradish peroxidase, True Blue, or Diamidino Yellow. One series of sections was processed to demonstrate the tracer and an adjacent series was processed to demonstrate acetylcholinesterase (AChE). In some cases, a series of sections was immunohistochemically processed to identify the presence of choline acetyltransferase (CAT), the synthesizing enzyme for acetylcholine. Approximately 1,700-1,800 OC neurons were contained in five distinct regions surrounding the major nuclei of the superior olivary complex (SOC), namely: dorsal to medial superior olive (MSO); between MSO and lateral superior olive (LSO); lateral to LSO; medial to SOC; and in the ventral nucleus of the tra...Continue Reading


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Related Concepts

Auditory Pathway Structure
Brain Stem
Choline O-Acetyltransferase
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