Olodaterol attenuates citric acid-induced cough in naïve and ovalbumin-sensitized and challenged guinea pigs

PloS One
Eva Wex, Thierry Bouyssou

Abstract

Excessive coughing is a common feature of airway diseases. Different G-protein coupled receptors, including β2-adrenergic receptors (β2-AR), have been implicated in the molecular mechanisms underlying the cough reflex. However, the potential antitussive property of β2-AR agonists in patients with respiratory disease is a matter of ongoing debate. The aim of our study was to test the efficacy of the long-acting β2-AR agonist olodaterol with regard to its antitussive property in a pre-clinical model of citric acid-induced cough in guinea pigs and to compare the results to different clinically relevant β2-AR agonists. In our study β2-AR agonists were intratracheally administered, as dry powder, into the lungs of naïve or ovalbumin-sensitized guinea pigs 15 minutes prior to induction of cough by exposure to citric acid. Cough events were counted over 15 minutes during the citric acid exposure. Olodaterol dose-dependently inhibited the number of cough events in naïve and even more potently and with a greater maximal efficacy in ovalbumin-sensitized guinea pigs (p < 0.01). Formoterol and salmeterol showed a trend towards reducing cough. On the contrary, indacaterol demonstrated pro-tussive properties as it significantly increased the...Continue Reading

References

Nov 1, 1991·British Journal of Clinical Pharmacology·N B ChoudryR W Fuller
Oct 1, 1987·British Journal of Clinical Pharmacology·R LowryD Godden
Oct 1, 1983·British Medical Journal·R Ellul-Micallef
Apr 24, 1995·European Journal of Pharmacology·D C BolserR W Chapman
Oct 15, 1998·Archives of Disease in Childhood·A B ChangC F Robertson
May 5, 2004·Pulmonary Pharmacology & Therapeutics·Siobhan MulrennanAlyn Morice
Sep 11, 2004·The European Respiratory Journal·A H MoriceUNKNOWN ERS Task Force
Feb 12, 2005·Chest·Benjamin PrudonIan D Pavord
Feb 15, 2005·Pulmonary Pharmacology & Therapeutics·Naoto WatanabeJohn V Priestley
Oct 4, 2005·Respiratory Medicine·Malcolm CampbellKlaus F Rabe
Aug 29, 2006·Thorax·A H MoriceUNKNOWN British Thoracic Society Cough Guideline Group
Jun 2, 2007·The European Respiratory Journal·A H MoriceUNKNOWN European Respiratory Society (ERS)
Apr 22, 2008·Lancet·Kian Fan Chung, Ian D Pavord
Nov 20, 2008·Chest·Pierre-Régis BurgelUNKNOWN Initiatives Bronchopneumopathie Chronique Obstructive (BPCO) Scientific Committee
Aug 15, 2009·The European Respiratory Journal·V C Freund-MichelM G Belvisi
Sep 19, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kunihiko TeradaMichiaki Mishima
Mar 10, 2010·BMC Pulmonary Medicine·Gregory FeldmanUNKNOWN INLIGHT 1 study group
Aug 3, 2010·The European Respiratory Journal·N OhkuraN Katayama
Oct 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brendan J Canning, Nanako Mori
Feb 5, 2011·Pulmonary Pharmacology & Therapeutics·Akio Niimi
Jul 6, 2011·Current Opinion in Pharmacology·Sarah A MaherMaria G Belvisi
Sep 23, 2011·COPD·James F Donohue, Fernando J Martinez
Feb 22, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tina Marie LieuBradley J Undem
Apr 14, 2012·Pharmacotherapy·Shaunta' M RayAndrea S Franks
Oct 26, 2013·Drugs·Andrew Gibb, Lily P H Yang

❮ Previous
Next ❯

Citations

May 14, 2016·Expert Opinion on Investigational Drugs·Mario CazzolaJosuel Ora
Oct 13, 2018·Expert Opinion on Pharmacotherapy·Andrea S Melani
Jul 16, 2020·British Journal of Pharmacology·Rachel Yoon Kyung ChangHak-Kim Chan
Feb 4, 2016·The Journal of Pharmacology and Experimental Therapeutics·Emlyn ClayClive Page
Aug 16, 2017·British Journal of Pharmacology·Franziska Elena HerrmannEva Wex

❮ Previous
Next ❯

Methods Mentioned

BETA
Electrophoresis
ELISA

Software Mentioned

GraphPad
Buxco Cough Analyser
Buxco
GraphPad Prism

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.