Olvanil: more potent than capsaicin at stimulating the efferent function of sensory nerves

European Journal of Pharmacology
S R HughesS D Brain


The capsaicin analogue olvanil stimulated an increase in cutaneous blood flow when injected intradermally into the anaesthetised rabbit, as measured using a 133Xenon clearance method. Olvanil was found to be a 10-fold more potent vasodilator (on a molar basis) than capsaicin. The effect of both vasodilators was significantly inhibited by the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP-(8-37). These findings suggest that olvanil stimulates the efferent function of cutaneous sensory nerves in a more potent manner than capsaicin. We therefore suggest that olvanil is a useful pharmacological tool for studying the activity of neuropeptides released from sensory nerves.


Sep 28, 1990·Biochemical and Biophysical Research Communications·S M GardinerB Hughes
Oct 13, 1987·European Journal of Pharmacology·A Franco-CerecedaJ M Lundberg
Jan 3, 1985·Nature·S D BrainI MacIntyre

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