Olvanil: more potent than capsaicin at stimulating the efferent function of sensory nerves

European Journal of Pharmacology
S R HughesS D Brain

Abstract

The capsaicin analogue olvanil stimulated an increase in cutaneous blood flow when injected intradermally into the anaesthetised rabbit, as measured using a 133Xenon clearance method. Olvanil was found to be a 10-fold more potent vasodilator (on a molar basis) than capsaicin. The effect of both vasodilators was significantly inhibited by the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP-(8-37). These findings suggest that olvanil stimulates the efferent function of cutaneous sensory nerves in a more potent manner than capsaicin. We therefore suggest that olvanil is a useful pharmacological tool for studying the activity of neuropeptides released from sensory nerves.

References

Sep 28, 1990·Biochemical and Biophysical Research Communications·S M GardinerB Hughes
Oct 13, 1987·European Journal of Pharmacology·A Franco-CerecedaJ M Lundberg
Jan 3, 1985·Nature·S D BrainI MacIntyre

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Citations

Oct 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M A PotenzaD Mitolo-Chieppa
Oct 24, 2001·European Journal of Pharmacology·V RalevicD Smart
Jun 27, 2003·European Journal of Pharmacology·Karin J StebbinsJames L Ellis
Jan 27, 1999·European Journal of Pharmacology·M Beltramo, D Piomelli
Feb 1, 1995·British Journal of Pharmacology·P Newbold, S D Brain
Jun 30, 2001·Japanese Journal of Pharmacology·K SatohT Nakamura
Jul 6, 2005·British Journal of Pharmacology·Pouya MovahedEdward D Högestätt
Aug 16, 2002·Molecular Pharmacology·David A AnderssonPeter M Zygmunt
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura

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