OM-85 BV for primary prevention of recurrent airway infections: a pilot randomized, double-blind, placebo-controlled study

Einstein
Fátima Cleonice de SouzaL A Pinto

Abstract

To compare the frequency of respiratory tract infections in children treated with OM-85 BV and placebo during the 3-month therapy period, and observation for a further 3 months after treatment. A randomized, double-blind, placebo-controlled trial was conducted with 54 children (6 months to 5 years old) with no past history of recurrent respiratory infections attending daycare center. Family members were instructed to administer one capsule per day for 10 consecutive days, for 3 months of OM-85 BV or placebo. Telephone interviews were conducted every 30 days. There was no significant difference in the number of respiratory infections between the groups. The mean number of respiratory tract infection in the OM-85 BV Group in the first 3 months was 0.92±0.87, and in the Placebo Group was 0.74±1.02, and at 6 months it was 1.62±1.47 and 1.03±1.34, respectively. OM-85 BV was not effective in the primary prevention of respiratory tract infections. Although most authors recommend the use of this immunostimulant in children with a history of recurrent respiratory infections, more studies are needed to define its usefulness in the primary prevention of respiratory infections in healthy children exposed to few risk factors.

References

May 23, 2000·The Pediatric Infectious Disease Journal·J O Klein
Sep 8, 2010·Lancet·William W BusseJames E Gern
Oct 6, 2010·The Journal of Allergy and Clinical Immunology·Cem Hasan RaziFersin Keskin
May 23, 2013·Multidisciplinary Respiratory Medicine·Fernando De Benedetto, Gianfranco Sevieri
Jul 28, 2016·The Pediatric Infectious Disease Journal·Laura ToivonenVille Peltola
Apr 3, 2019·International Journal of Environmental Research and Public Health·Susanna EspositoNicola Principi

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