Abstract
Aspirin desensitization has been associated with benefit in management of aspirin-exacerbated respiratory disease (AERD). An intervention that would encourage aspirin desensitization to be performed more frequently has substantial potential for improving outcomes and quality of life in patients with AERD. We investigated whether omalizumab administration would be associated with attenuation of aspirin-provoked bronchospasm in patients with AERD undergoing aspirin desensitization. We carried out a randomized, double-blind, placebo-controlled study in which subjects with AERD who fulfilled label criteria for omalizumab received omalizumab or placebo for 16 weeks, and then underwent aspirin desensitization. Eleven subjects completed aspirin desensitization. Of the 7 who were randomized to omalizumab, 5 had no respiratory reaction during aspirin desensitization. Compared with placebo, omalizumab was associated with a significantly greater likelihood for subjects with AERD to have no respiratory reaction during desensitization (P = .04, Fisher exact test). There was an overall difference in urinary leukotriene E4 (LTE4) levels in subjects who received omalizumab and did not have a respiratory reaction during desensitization compared...Continue Reading
Citations
Nov 23, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Angelica TiotiuAndras Bikov
Apr 15, 2020·American Journal of Respiratory and Critical Care Medicine·William W Busse
May 14, 2020·Current Opinion in Allergy and Clinical Immunology·Javier FernandezNatalia Blanca-Lopez
Sep 25, 2020·American Journal of Rhinology & Allergy·S Shahzad MustafaAllison Ramsey
Aug 28, 2020·Frontiers in Pharmacology·Seong-Dae WooHae-Sim Park
Mar 20, 2019·Medical Sciences : Open Access Journal·Kevin L LiWaleed M Abuzeid
Feb 6, 2020·Clinical and Translational Allergy·Hanneke N G Oude ElberinkAnnick A J M van de Ven
Dec 12, 2020·The Journal of Allergy and Clinical Immunology·Whitney W StevensAndrew A White
Oct 17, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kathleen M Buchheit, Kathryn E Hulse
Mar 25, 2021·The Journal of Allergy and Clinical Immunology·Claus BachertWilliam W Busse
Jan 29, 2019·The Journal of Allergy and Clinical Immunology·Juan Carlos Cardet, Thomas B Casale
Oct 8, 2019·The Journal of Allergy and Clinical Immunology·Joshua A Boyce
Aug 9, 2021·The Journal of Allergy and Clinical Immunology·Rubaiyat HaqueClaire Hopkins
Aug 9, 2021·The Journal of Allergy and Clinical Immunology·Ryan EidLarry Borish
Sep 19, 2021·Clinical Reviews in Allergy & Immunology·Philippe GevaertTara F Carr
Sep 21, 2021·The Journal of Allergy and Clinical Immunology·Paul OykhmanDerek K Chu
Oct 23, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Tamara QuintChristine Bangert