Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with cirrhosis (ABACUS): a prospective observational study.

The Lancet. Gastroenterology & Hepatology
Salvatore PettaAIFA team

Abstract

We ran a compassionate use nationwide programme (ABACUS) to provide access to ombitasvir, paritaprevir, and ritonavir, with dasabuvir, plus ribavirin for hepatitis C virus (HCV) genotype 1 infection and ombitasvir, paritaprevir, and ritonavir, plus ribavirin for HCV genotype 4 infection in patients with cirrhosis at high risk of decompensation while approval of these regimens was pending in Italy. In this prospective observational study, we collected data from a compassionate use nationwide programme from March 17, 2014, to May 28, 2015. Patients with HCV genotype 1 infection and cirrhosis at high risk of decompensation were given coformulated ombitasvir (25 mg), paritaprevir (150 mg), and ritonavir (100 mg) once daily and dasabuvir (250 mg) twice daily for 12 weeks (patients with HCV genotype 1b infection) or 24 weeks (patients with HCV genotype 1a infection). Patients with HCV genotype 4 infection were given coformulated ombitasvir (25 mg), paritaprevir (150 mg), and ritonavir (100 mg) once per day for 24 weeks. All patients were given weight-based ribavirin. The primary efficacy endpoint was sustained virological response at week 12 after the end of treatment (SVR12), analysed by intention-to-treat. Univariate and multivaria...Continue Reading

Citations

Aug 18, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Carmen M PredaAlexandru Oproiu
Aug 31, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Marc PuigvehíJosé A Carrión
Nov 24, 2018·Virology Journal·Antonio Di BiagioGiovanni Cenderello
May 3, 2019·Clinical and Molecular Hepatology·Tommaso Lorenzo ParigiAlessio Aghemo
Sep 29, 2018·Scientia pharmaceutica·Jürgen Krauß, Franz Bracher
Jun 11, 2020·Seminars in Arthritis and Rheumatism·Gonçalo BoletoDavid Saadoun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.