Omega-3 and omega-6 fatty acids and PGE2 stimulate the growth of normal but not tumor mouse mammary epithelial cells: evidence for alterations in the signaling pathways in tumor cells

Prostaglandins, Leukotrienes, and Essential Fatty Acids
K E McKenzieS Nandi

Abstract

The direct effect of omega-3 and omega-6 fatty acids on the proliferation of mouse mammary tumor cells (MTC) was examined in a serum-free cell culture system. While the EGF-induced proliferation of normal mammary epithelial cells was shown to be enhanced by omega-3 and omega-6 fatty acids and prostaglandins (PGs), a majority (75-80%) of primary mammary tumors were not stimulated by these agents. Compared to normal cells, some MTC cultures showed a higher susceptibility to inhibition by omega-3 fatty acids. The general lack of response of MTC cultures to PGE2 and cyclic adenosine monophosphate (cAMP) suggests some alterations in the cAMP-mediated pathway. However, the PGE2-induced cAMP levels and cAMP-dependent protein kinase (PKA) activities in the tumor cells were comparable to normal cells. We conclude that the proliferation of mammary tumor cells either follow a cAMP-PKA-independent pathway or have some alterations in the serine/threonine kinase mediated signaling pathway.

References

Aug 19, 1991·International Journal of Cancer. Journal International Du Cancer·M R YoungJ M Bagash
Jan 1, 1990·Nutrition Reviews·K L Erickson, N E Hubbard
Sep 24, 1990·Biochimica Et Biophysica Acta·D S Lester
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J L MeinkothJ R Feramisco
Jan 1, 1989·Nutrition and Cancer·L KaizerD Tritchler
Apr 6, 1988·Journal of the National Cancer Institute·M E BéginD F Horrobin
Jul 1, 1987·Preventive Medicine·L A Cohen
Jan 1, 1987·The American Journal of Clinical Nutrition·C W Welsch
May 29, 1987·Biochemical and Biophysical Research Communications·U N DasD F Horrobin
Apr 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·L J FaulkinL A Hillyard
Feb 1, 1980·Journal of the National Cancer Institute·R A KnazekB K Vonderhaar
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W ImagawaS Nandi
Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·N H Nielsen, J P Hansen

❮ Previous
Next ❯

Citations

Aug 1, 1996·Journal of Cellular Physiology·Y K HomS Nandi
Jan 3, 2012·International Journal of Molecular Medicine·Kojiro Yano
Apr 29, 2006·Journal of Cellular Physiology·Diana Nieves, Juan José Moreno
Feb 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G K BandyopadhyayS Nandi
Dec 15, 2005·International Journal of Cancer. Journal International Du Cancer·Magnus LindskogJohn Inge Johnsen
Apr 24, 2007·Nature Cell Biology·Christopher J SarkisianLewis A Chodosh
Apr 9, 1998·Biochimica Et Biophysica Acta·R L KongerA P Pentland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Qiong ZhouMing Bai
Journal of Nutritional Science and Vitaminology
R KishimotoS S Park
© 2021 Meta ULC. All rights reserved