PMID: 9555791Apr 29, 1998Paper

Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial

Journal of the American Academy of Dermatology
P MayserF Grimminger

Abstract

Profound changes in the metabolism of eicosanoids with increased concentrations of free arachidonic acid (AA) and its proinflammatory metabolites have been observed in psoriatic lesions. Free eicosapentaenoic acid (EPA) may compete with liberated AA and result in an antiinflammatory effect. Our purpose was to assess the efficacy and safety of intravenously administered fish-oil-derived lipid emulsion on chronic plaque-type psoriasis. A double-blind, randomized, parallel group study was performed in eight European centers. Eighty-three patients hospitalized for chronic plaque-type psoriasis with a severity score of at least 15 according to the Psoriasis Area and Severity Index (PASI) participated in a 14-day trial. They were randomly allocated to receive daily infusions with either a omega-3 fatty acid-based lipid emulsion (Omegavenous; 200 ml/day with 4.2 gm of both EPA and docosahexaenoic acid (DHA); 43 patients) or a conventional omega-6-lipid emulsion (Lipovenous; EPA+DHA < 0.1 gm/100 ml; 40 patients). The groups were well matched with respect to demographic data and psoriasis-specific medical history. Efficacy of therapy was evaluated by changes in PASI, in an overall assessment of psoriasis by the investigator, and a self-...Continue Reading

Associated Clinical Trials

References

Jan 1, 1978·Dermatologica·T Fredriksson, U Pettersson
Mar 1, 1991·The American Journal of Clinical Nutrition·K YamazakiF Ibuki
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J PetersonT Olivecrona
May 1, 1987·The Journal of Investigative Dermatology·K KragballeE J Goetzl
Jul 1, 1989·Journal of Cellular Biochemistry·V G Mahadevappa, W S Powell
Dec 1, 1985·The Journal of Clinical Investigation·C von Schacky, P C Weber
Oct 1, 1988·The American Journal of Clinical Nutrition·W S HarrisC A Dujovne
Dec 1, 1984·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·M NadeauP Borgeat
Nov 30, 1983·Biochemical and Biophysical Research Communications·D W GoldmanE J Goetzl
Jan 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F Grimminger, P Mayser
Nov 1, 1993·Analytical Biochemistry·H J KrämerW Seeger
Jul 1, 1996·International Archives of Allergy and Immunology·E Christophers

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Citations

Jun 8, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Wolters
May 26, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Evangelos TsekosGerhard Boeden
Apr 18, 2002·Thrombosis Research·Chitra KrishnamurtiStephen W Rothwell
Jul 17, 2009·The British Journal of Nutrition·P C CalderJ Zhao
Mar 18, 2006·Arthritis Research & Therapy·Leslie G ClelandSusanna M Proudman
Apr 8, 2003·Drugs·Leslie G ClelandSusanna M Proudman
Oct 15, 2013·Nutrition Reviews·Michael R FlockPenny M Kris-Etherton
Oct 29, 2013·Clinics in Dermatology·Nikita LakdawalaJane M Grant-Kels
Nov 3, 2010·Clinics in Dermatology·Janelle R RickettsJane M Grant-Kels
Aug 12, 2009·Journal of the American Academy of Dermatology·Nana SmithJoel M Gelfand
Apr 18, 2013·Diabetes/metabolism Research and Reviews·Michael R FlockPenny M Kris-Etherton
May 2, 2014·Journal of the American Academy of Dermatology·Jillian W MillsopWilson Liao
Apr 2, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Karina V BarrosVera L F Silveira
Jul 14, 2010·Clinics in Dermatology·Meagen M McCusker, Jane M Grant-Kels
Jun 29, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Dan L WaitzbergThiago Manzoni Jacintho
Mar 9, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Karina V BarrosVera L Flor Silveira
May 29, 2004·Integrative Cancer Therapies·David H JhoN Joseph Espat
Jul 17, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Dan Linetzky Waitzberg, Raquel Susana Torrinhas
Mar 2, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Vincent W VanekUNKNOWN American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C R SimpsonR N Barker
Sep 8, 2018·JAMA Dermatology·A Caresse GamretAnna J Nichols
Aug 17, 2005·International Journal of Dermatology·Amy C BrownSerena Lo
Sep 27, 2005·The British Journal of Dermatology·M Wolters
Aug 30, 2008·The British Journal of Dermatology·A P TownshendH C Williams
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·I E Dupont, Y A Carpentier
May 29, 2020·Journal of Cutaneous Medicine and Surgery·Bryce J ThomsenMariusz J Sapijaszko
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickUNKNOWN American Association of Clinical Endocrinologists
Mar 16, 2002·The British Journal of Nutrition·P MayserF Grimminger
Jan 20, 2007·Journal of Cutaneous Medicine and Surgery·Yves PoulinPatrice E Poubelle
Mar 7, 2017·International Journal of Rheumatic Diseases·Sikarin UpalaAnawin Sanguankeo
May 21, 2017·Dermatology and Therapy·Ladan AfifiWilson Liao
Apr 5, 2018·Scientific Reports·Natsuko Saito-SasakiMotonobu Nakamura
Aug 23, 2019·Therapeutic Advances in Chronic Disease·Hristina KocicKetty Peris
Sep 26, 2003·The Proceedings of the Nutrition Society·Lucy M Browning
Dec 7, 2019·BMC Complementary and Alternative Medicine·Shih-Jyun Yang, Ching-Chi Chi
Apr 15, 2003·The Proceedings of the Nutrition Society·W Martin HowellRobert F Grimble

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