Omega-3 fatty acid supplementation may prevent loss of gray matter thickness in the left parieto-occipital cortex in first episode schizophrenia: A secondary outcome analysis of the OFFER randomized controlled study

Schizophrenia Research
Tomasz PawełczykAgnieszka Pawełczyk

Abstract

The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containing 2.2g/d of eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) or placebo (olive oil). Participants underwent MRI scanning twice to assess changes in cortical thickness: at the beginning and at the end of intervention. Data of suitable quality was obtained from 29 participants. The T1-weighted images for each participant were analyzed using FreeSurfer methodology for longitudinal pipeline. Significant differences in cortical thickness loss were observed between the groups in the parieto-occipital regions of Brodmann areas 7 and 19 of the left hemisphere, dysfunctions in which may be involved in schizophrenia symptomatology. The results of the study support the previous observations carried out in older individuals and patients with mild cognitive impairment, indicating that n-3 PUFA may have neuroprotective properties, especially at early stages of neurodegenerative diseases, such as schizophrenia. If replicated...Continue Reading

Citations

Apr 28, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Peiyan Ni, Sangmi Chung
Sep 10, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Joseph FirthJerome Sarris
Oct 17, 2018·Proceedings of the National Academy of Sciences of the United States of America·Bruce N Ames
Jun 4, 2020·International Journal of Environmental Research and Public Health·Octavio PanoJ Alfredo Martínez
Mar 19, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marta Casquero-VeigaMaría Luisa Soto-Montenegro

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