Omega-3 fatty acids administered in phosphatidylserine improved certain aspects of high chronic stress in men

Nutrition Research
Juliane HellhammerMelanie Schubert

Abstract

Nutrients such as omega-3 oils and phosphatidylserine have been considered to exert stress-buffering effects. In this randomized, double-blind, placebo-controlled trial, we investigated effects of omega-3 phosphatidylserine (PS) on perceived chronic stress, assessed by the Trier Inventory for Chronic Stress (Schulz P, Schlotz W, Becker P. TICS: Trierer Inventar zum chronischen Stress. Göttingen, Germany: Hogrefe, 2004.), and on psychobiological stress responses to an acute laboratory stress protocol, the Trier Social Stress Test (Neuropsychobiology.1993;28:76-81), at baseline and after the treatment period. We hypothesized that omega-3 PS supplementation lowers chronic and acute stress. Sixty healthy nonsmoking men aged 30 to 60 years either received omega-3 PS or a matching placebo for 12 weeks. Results revealed no significant main effect of omega-3 PS supplementation on stress measures. However, by accounting for chronic stress level of study participants, stress-reducing effects of omega-3 PS were found exclusively for high chronically stressed subjects. As expected, these individuals also showed a blunted cortisol response to the Trier Social Stress Test. Treatment with omega-3 PS seemed to restore the cortisol response in ...Continue Reading

References

Jan 1, 1995·Journal of Health and Social Behavior·P A Thoits
Jan 1, 1993·Psychotherapy and Psychosomatics·D H Hellhammer, S Wade
Sep 11, 2004·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·C H S RuxtonK J Millington
Oct 30, 2004·Stress : the International Journal on the Biology of Stress·J HellhammerD Hellhammer
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Ilona S FederenkoStefan Wüst
May 14, 2005·Brain, Behavior, and Immunity·Roland von KänelJoachim E Fischer
Jun 14, 2005·Psychoneuroendocrinology·Eva FriesDirk H Hellhammer
Sep 5, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert K McNamara, Susan E Carlson
Apr 14, 2007·Acta Psychiatrica Scandinavica·A R TyrkaL L Carpenter
Oct 19, 2007·Psychosomatic Medicine·Dana A GleiMaxine Weinstein
Aug 16, 2008·The European Journal of Neuroscience·Marcus IsingFlorian Holsboer
Jun 1, 2005·Nutrition Research Reviews·Mark HamerJoris Kloek
Dec 20, 2008·Psychoneuroendocrinology·Dirk H HellhammerBrigitte M Kudielka
Jun 3, 2009·Nature Reviews. Endocrinology·George P Chrousos
Oct 20, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Johannes SchultJuliane Hellhammer
Jan 29, 2010·Stress : the International Journal on the Biology of Stress·Brigitte M Kudielka, Stefan Wüst
Feb 5, 2010·The American Journal of Clinical Nutrition·Katherine M AppletonAndrew R Ness
Oct 12, 2010·Nutrition Journal·Shaheen E Lakhan, Karen F Vieira
Oct 12, 2010·Journal of the International Society of Sports Nutrition·Eric E NoreenLindsay K Averill
Oct 23, 2010·Journal of Psychiatry & Neuroscience : JPN·Veronika EngertJens C Pruessner
Jul 26, 2011·Brain, Behavior, and Immunity·Janice K Kiecolt-GlaserRonald Glaser

❮ Previous
Next ❯

Citations

Nov 19, 2013·Neuroscience and Biobehavioral Reviews·Andrew P AllenGerard Clarke
Jul 1, 2017·Critical Reviews in Food Science and Nutrition·Carlos CardosoNarcisa M Bandarra
Nov 22, 2016·Nutrition Research Reviews·Carlos CardosoNarcisa M Bandarra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.