Omega-3 fatty acids attenuate glomerular capillary hydraulic pressure in rats with renal ablation

Kidney International
P G SchmitzB J Majidi

Abstract

To clarify the emerging role of omega-3 fatty acids (FAs) in the regulation of the renal microcirculation, we recently performed micropuncture studies in normal rats maintained on diets enriched with omega-3 FAs. Although those studies suggested that omega-3 FAs alter the renal microcirculation in normal rats, it was not apparent whether this dietary maneuver could modulate intrarenal hemodynamics in the setting of renal disease. Therefore, the present renal micropuncture studies were performed in nephrectomized rats maintained on control diets or diets enriched with omega-3 FAs. Omega-3 FAs abrogated glomerular capillary (56.2 +/- 0.8 vs. 63.9 +/- 2.0 mm Hg) and transcapillary hydraulic pressure (40.9 +/- 1.4 vs. 50.6 +/- 1.3 mm Hg) compared to untreated rats. This effect was attributable to (1) a reduction in mean arterial pressure (138 +/- 3 vs. 163 +/- 2 mm Hg) and (2) a decrease in efferent arteriolar resistance (0.43 +/- 0.06 vs 0.98 +/- 0.19 dyn x seconds x cm-5 x 10(10)). Sclerosis index and albuminuria were also lessened by this dietary maneuver. To further characterize the mechanism of altered renal arteriolar resistance, we then explored the effects of omega-3 FAs on renal prostaglandin synthesis and angiotensin II-s...Continue Reading

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Citations

Dec 17, 2003·Kidney International·Efstathios Alexopoulos
Feb 15, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C Valente GambaF Zaladek Gil
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Paul G SchmitzMary E Gellens

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