Omega-3 fatty acids, cognitive decline, and Alzheimer's disease: a critical review and evaluation of the literature

Journal of Alzheimer's Disease : JAD
Tina L Huang

Abstract

The precipitous decline of memory and independence associated with cognitive decline, dementia, and Alzheimer's disease is emotionally and financially devastating to patients, their families, and caretakers. Studies from animal models and cell cultures have shown that omega-3 fatty acids (n-3 FAs) are neuroprotective during development and aging. Numerous epidemiologic, postmortem, and clinical trials have been published on fish or n-3 FAs and Alzheimer's disease, dementia, or cognitive decline. Yet results across the literature in humans are inconsistent and thus difficult to interpret. This review provides background and context needed for interpretation of the findings, summaries of the literature grouped by longitudinal studies of fish, dietary n-3 FAs, blood levels of fatty acids, postmortem studies, and clinical trials, and subsequent interpretation of findings. Possible reasons for discrepancies in the literature are presented throughout, and conclusions suggest directions for future research.

Citations

May 4, 2011·Current Opinion in Lipidology·Jun YangBruce D Hammock
Aug 14, 2018·Food & Function·Theresa GreupnerJan Philipp Schuchardt
Mar 26, 2019·Annual Review of Food Science and Technology·Rebecca PowerJohn M Nolan
May 25, 2012·The British Journal of Nutrition·Natalia UbedaGregorio Varela-Moreiras
May 25, 2012·The British Journal of Nutrition·Alan D DangourRicardo Uauy
Jun 21, 2012·European Journal of Clinical Nutrition·E RönnemaaL Kilander
Feb 26, 2015·The British Journal of Nutrition·Luz SanguansriGlen S Patten
Sep 21, 2012·Journal of Cardiovascular Translational Research·Wei ZhuangZhenyu Deng
Dec 12, 2012·Annual Review of Food Science and Technology·Bingcan ChenEric Andrew Decker
Oct 22, 2014·The American Journal of Clinical Nutrition·Sharon G CurhanGary C Curhan
Jan 10, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sven J van der LeeCornelia M van Duijn
May 31, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Hugo GeertsUNKNOWN Brain Health Modeling Initiative (BHMI)
Feb 27, 2020·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Anne Cecilie Sjøli BråthenKristine B Walhovd
Mar 5, 2013·Journal of Nutrition in Gerontology and Geriatrics·Martin Loef, Harald Walach
Jul 2, 2019·Therapeutic Advances in Psychopharmacology·Arne Reimers, Hanna Ljung
Apr 10, 2020·Neuronal Signaling·Holly C HunsbergerMiranda N Reed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Related Papers

Hormones and Behavior
Meharvan Singh, Chang Su
International Journal of Aging & Human Development
E E Malonebeach, S H Zarit
© 2021 Meta ULC. All rights reserved