Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.

The Cochrane Database of Systematic Reviews
Asmaa AbdelhamidLee Hooper

Abstract

Researchers have suggested that omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants (alpha-linolenic acid (ALA)) benefit cardiovascular health. Guidelines recommend increasing omega-3-rich foods, and sometimes supplementation, but recent trials have not confirmed this. To assess effects of increased intake of fish- and plant-based omega-3 for all-cause mortality, cardiovascular (CVD) events, adiposity and lipids. We searched CENTRAL, MEDLINE and Embase to April 2017, plus ClinicalTrials.gov and World Health Organization International Clinical Trials Registry to September 2016, with no language restrictions. We handsearched systematic review references and bibliographies and contacted authors. We included randomised controlled trials (RCTs) that lasted at least 12 months and compared supplementation and/or advice to increase LCn3 or ALA intake versus usual or lower intake. Two review authors independently assessed studies for inclusion, extracted data and assessed validity. We performed separate random-effects meta-analysis for ALA and LCn3 interventions, and assessed dose-response relationships through meta-r...Continue Reading

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Citations

Jul 19, 2018·The Cochrane Database of Systematic Reviews·Lee HooperKatherine Ho Deane
Jul 19, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Nov 30, 2018·The Cochrane Database of Systematic Reviews·Lee HooperKatherine Ho Deane
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Nov 30, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
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