Omega-3 fatty acids modulate cyclophosphamide induced markers of immunosuppression and oxidative stress in pigs

Scientific Reports
Sang In Lee, Kyung Soo Kang

Abstract

Immunosuppression directly correlates with economic benefits in livestock. Although omega-3, known as an energy source, is used as a pharmaceutical molecule, it remains unknown whether dietary supplementation with omega-3 can alleviate cyclophosphamide-induced immunosuppression in pigs. Omega-3 treatment increased the number of white blood cell, lymphocytes, and monocytes and decreased tumor necrosis factor (TNF)-α production under CTX challenge. In addition, we confirmed that omega-3 decreased the expression of nuclear factor (NF)-κB, TNF-α, interferon (IFN)-γ, and interleukin (IL)-8 in peripheral blood mononuclear cells. Additionally, omega-3 alleviated the activities of liver injury markers (alanine transaminase [ALT] and aspartate transaminase [AST]) and modulated oxidative stress markers (superoxide dismutase [SOD], malondialdehyde [MDA], and glutathione peroxidase [GPx]) in the blood serum after the CTX challenge. Based on these results, we suggest that omega-3 treatment modulates CTX-induced immunosuppression and oxidative stress in pigs. These results may have important implications in the development of new therapeutic approaches to improve immunosuppression, hepatic injury and dysfunction, and oxidative stress in pigs.

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Citations

Feb 23, 2020·Expert Opinion on Therapeutic Targets·Pei FanJianke Li
Jun 18, 2020·Drug Design, Development and Therapy·Xiao-Nan ZhaoHong-Yan Li
Jan 26, 2021·Oxidative Medicine and Cellular Longevity·Xiaoqing ChiSonghua Hu
Jul 23, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Shanshan ChenYing Wang

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Methods Mentioned

BETA
ELISA
ELISAs
MDA
enzyme-linked immunosorbent assay
density gradient centrifugation

Software Mentioned

Primer3
SAS

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