Omega-3 free fatty acids inhibit tamoxifen-induced cell apoptosis

Biochemical and Biophysical Research Communications
Shufan WuYong Q Chen

Abstract

Fish oil, which contains omega-3 fatty acids mainly in the form of triglycerides, has benefits for reducing breast cancer risk, similar to tamoxifen action. However, it remains to be elucidated whether the combination of omega-3 free fatty acid (ω-3FFA) with tamoxifen leads to improved treatment in breast cancer. In this study, we observed that ω-3FFA induces MCF-7 cell apoptosis to suppress cell growth. The treatment of breast cancer cells with ω-3FFA attenuated tamoxifen-induced cell apoptosis. ω-3FFA and tamoxifen significantly increased Erk1/2 and Akt phosphorylation levels in a dose and time dependent manner. Compared to ω-3FFA alone, the combination of tamoxifen with ω-3FFA significantly increased Erk1/2 and Akt phosphorylation levels. Because Erk1/2 and Akt activation has been linked to tamoxifen-related anti-estrogen resistance in breast cancer patients, these results indicate that ω-3FFA may interfere with the effects of tamoxifen in the prevention of breast cancer risk.

References

Mar 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V KleinP Bougnoux
Jan 29, 2003·The Journal of Nutritional Biochemistry·Hilda ChamrasJohn A. Glaspy
Jun 17, 2004·Journal of the National Cancer Institute·Jiang ShouRachel Schiff
Sep 21, 2004·Breast Cancer Research and Treatment·Nicola J JordanRobert I Nicholson
Mar 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Carolina GutierrezMitch Dowsett
Jun 30, 2005·Breast Cancer Research and Treatment·Patricia D SchleyCatherine J Field
Aug 10, 2005·The Journal of Pathology·Tove KirkegaardJohn M S Bartlett
May 18, 2006·Journal of the National Cancer Institute·Caroline HolmGöran Landberg
Jun 10, 2008·Free Radical Biology & Medicine·Sang Kyum KimKeon Wook Kang
Aug 25, 2009·Nature Reviews. Cancer·Elizabeth A Musgrove, Robert L Sutherland
Sep 1, 2009·Progress in Lipid Research·Philippe BougnouxStephan Chevalier
Apr 29, 2010·Molecular Nutrition & Food Research·Jennifer S TruanLilian U Thompson
Oct 26, 2010·Biochemical and Biophysical Research Communications·Chandi Charan MandalNandini Ghosh-Choudhury
Oct 15, 2013·International Journal of Cancer. Journal International Du Cancer·Andrea ManniKaram El-Bayoumy
Aug 1, 2014·The Journal of Pharmacology and Experimental Therapeutics·Nuha Al-ZaubaiAlastair G Stewart
Nov 13, 2014·TheScientificWorldJournal·Jihene Elloumi-MseddiSami Aifa

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Citations

Apr 5, 2016·Chemico-biological Interactions·Christine G SkibinskiKaram El-Bayoumy
Feb 13, 2018·Experimental and Therapeutic Medicine·Oana ZanoagaIoana Berindan-Neagoe
Nov 9, 2017·Scientific Reports·Hailan WuZhao He
Jul 16, 2019·Food Science of Animal Resources·Utthapon IssaraSungkwon Park
Apr 9, 2018·Molecular Aspects of Medicine·Natividad R FuentesRobert S Chapkin
Aug 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aliyu MuhammadIbrahim Babangida Abubakar

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