Omega-3 polyunsaturated fatty acids and bronchial inflammation in grass pollen allergy after allergen challenge

Respiratory Medicine
Richard KitzStefan Zielen

Abstract

RATIO: Asthma is a major public health problem, with bronchial inflammation as the therapeutic target. The role of dietary fish oil derived polyunsaturated fatty acids (PUFAs) in allergic inflammation is controversial. Most asthmatics suffer from mild disease and non-pharmacologic interventions are attractive. This study investigates the anti-inflammatory potential of nutritional PUFAs in an experimentally induced bronchial inflammation. We examined 38 grass pollen allergic asthmatics and 19 controls. History of dietary PUFA intake was compared with levels of PUFAs in erythrocyte membranes, and stratified according to low (25th quartile; Q25) and high (75th quartile; Q75) ratios of omega-3 (n-3) to omega-6 (n-6) PUFAs as a surrogate for anti-inflammatory (Q75) or proinflammatory (Q25) effects. Bronchial inflammation was simulated with one-step inhalation of grass pollen. Bronchial response (exhaled nitric monoxide, eNO as surrogate for inflammation, decrease of FEV(1)) was correlated with levels of PUFAs in erythrocyte membranes. Ratios of n-3/n-6 PUFA were significantly lower in asthmatics than in healthy controls. Levels of eNO were significantly higher in Q25 asthmatics than in Q75 asthmatics (p = 0.040). There was a trend o...Continue Reading

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Citations

Apr 5, 2013·Pediatric Allergy, Immunology, and Pulmonology·Rita de Cássia Ribeiro SilvaNeuza Maria Alcantara-Neves
Sep 20, 2015·Free Radical Biology & Medicine·Meghan Delmastro-GreenwoodStacy Gelhaus Wendell
Apr 5, 2016·European Journal of Pharmacology·Linette E M Willemsen
Aug 4, 2015·Critical Reviews in Food Science and Nutrition·Xianyong MaChaoqiang Lai
Jan 13, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Jun Miyata, Makoto Arita
Mar 13, 2014·The Journal of Allergy and Clinical Immunology·Stacy Gelhaus WendellFernando Holguin
Jun 12, 2016·Cytokine·Shirin FarjadianSaeed Hosseini Teshnizi
Jul 25, 2015·The European Respiratory Journal·Gail M GauvreauPaul M O'Byrne

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