Omega-3 Polyunsaturated Fatty Acids Intake to Regulate Helicobacter pylori-Associated Gastric Diseases as Nonantimicrobial Dietary Approach

BioMed Research International
Jong-Min ParkKi-Baik Hahm

Abstract

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), commonly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been acknowledged as essential long-chain fatty acids imposing either optimal health promotion or the rescuing from chronic inflammatory diseases such as atherosclerosis, fatty liver, and various inflammatory gastrointestinal diseases. Recent studies dealing with EPA and DHA have sparked highest interests because detailed molecular mechanisms had been documented with the identification of its receptor, G protein coupled receptor, and GPR120. In this review article, we have described clear evidences showing that n-3 PUFAs could reduce various Helicobacter pylori- (H. pylori-) associated gastric diseases and extended to play even cancer preventive outcomes including H. pylori-associated gastric cancer by influencing multiple targets, including proliferation, survival, angiogenesis, inflammation, and metastasis. Since our previous studies strongly concluded that nonantimicrobial dietary approach for reducing inflammation, for instance, application of phytoceuticals, probiotics, natural products including Korean red ginseng, and walnut plentiful of n-3 PUFAs, might be prerequisite step for preventing H. pylori-...Continue Reading

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Citations

Oct 30, 2016·The Journal of Infection·Marie-Odile HussonFrédéric Gottrand
Aug 24, 2017·Helicobacter·Hidenori MatsuiMasahiko Nakamura
Feb 22, 2018·Cancer Biotherapy & Radiopharmaceuticals·Guohao LuHongyu Zheng
Feb 8, 2020·Nanomedicine·Qianyu ZhangXuefeng Xia
Apr 13, 2019·Journal of Cellular Biochemistry·Abolfazl Zendehdel, Maryam Roham

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Methods Mentioned

BETA
xenograft
electron spin resonance

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