Omega-3 polyunsaturated fatty acids supplementation in patients with diabetes and cardiovascular disease risk: does dose really matter?

Cardiovascular Diabetology
Alexander Tenenbaum, Enrique Z Fisman

Abstract

There is a vast disagreement in relation to the possible beneficial effects of omega-3 polyunsaturated fatty acids (omega-3 PUFA) supplementation in patients with diabetes and cardiovascular disease. The conflicting results between the various original studies and meta-analyses could be partially explained as a result of variable supplementation dosage and duration, either of which may modify the effects of omega-3 PUFA on cardio-metabolic biomarkers. Meta-analyses are limited usually by the inability to draw inferences regarding dosage, duration and the interaction of dosage and duration of omega-3 PUFA intake. Even so, almost all endpoints in the so-called "negative" meta-analyses leaned toward a trend for benefit with a near 10% reduction in cardiovascular outcomes and a borderline statistical significance. Many trials included in these meta-analyses tested an insufficient daily dose of omega-3 PUFA of less than 1000 mg. Probably, the consistent cardiovascular effects of omega-3 PUFA supplements could be expected only with daily doses above 2000 mg.

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Citations

Jun 18, 2020·European Journal of Hospital Pharmacy. Science and Practice·Maria Francesca CabidduMarco Chiumente
May 10, 2019·Frontiers in Immunology·Ana María Ruiz-LeónRosa Casas
Jun 9, 2021·The Journal of Nutritional Biochemistry·Salma M Eraky, Nehal M Ramadan
Nov 7, 2020·Journal of Bioenergetics and Biomembranes·Ricardo Mejía-Zepeda, Ismael Herminio Pérez-Hernández
Dec 12, 2021·Journal of the Science of Food and Agriculture·Xue ChenHong Zhu

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