Omega-3 supplementation to prevent recurrent preterm birth: a systematic review and metaanalysis of randomized controlled trials

American Journal of Obstetrics and Gynecology
Gabriele Saccone, Vincenzo Berghella

Abstract

The purpose of this study was to evaluate the efficacy of omega-3 supplementation for the prevention of recurrent preterm birth (PTB) in asymptomatic singleton gestations with previous PTB. We searched fish oil, long chain polyunsaturated fatty acids, pregnancy, and omega-3 in MEDLINE, OVID, Scopus, ClinicalTrials.gov, the PROSPERO International Prospective Register of Systematic Reviews, EMBASE, and the Cochrane Central Register of Controlled Trials from inception of each database to December 2014 with no limit for language. In addition the reference lists of all identified articles were examined to identify studies that were not captured by electronic searches. We performed a metaanalysis of randomized controlled trials of asymptomatic singleton gestations with previous PTB who were assigned randomly to prophylactic omega-3 supplementation vs control (either placebo or no treatment). The primary outcome was predefined as PTB at <37 weeks of gestation. The pooled results were reported as relative risk (RR) with 95% confidence interval (95% CI). The protocol of this review was registered with PROSPERO (registration number: CRD42015016371). Two randomized controlled trials that included 1080 women were analyzed. The mean gestati...Continue Reading

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Citations

Sep 19, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gabriele SacconeVincenzo Berghella
Feb 3, 2016·Journal of the Marine Biological Association of the United Kingdom·Matthew O GribbleCelia Y Chen
Jun 3, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G SacconeP Martinelli
Mar 13, 2016·Irish Journal of Medical Science·L MullaneyM J Turner
Jan 30, 2014·PloS One·Catherine G SutcliffeWilliam J Moss
Feb 24, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Gabriele Saccone, Vincenzo Berghella
Apr 12, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Gabriele SacconeVincenzo Berghella
May 28, 2017·American Journal of Obstetrics and Gynecology·Spencer G KuperAlan T Tita
Jun 16, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rupsa C BoeligVincenzo Berghella
Mar 30, 2017·Issues in Mental Health Nursing·Lisa RobertsRatan Singh
Mar 16, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·V BerghellaG Saccone
Feb 1, 2017·Journal of Perinatal Medicine·Alireza OstadrahimiAzizeh Farshbaf-Khalili
Nov 28, 2018·The Cochrane Database of Systematic Reviews·Philippa MiddletonMaria Makrides
Oct 16, 2018·Minerva ginecologica·Rossana Di SarnoGabriele Saccone
Dec 21, 2017·JAMA : the Journal of the American Medical Association·Gabriele SacconeUNKNOWN Italian Preterm Birth Prevention (IPP) Working Group
Jan 25, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giovanni NazzaroMariavittoria Locci
Jan 6, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Reshama NavatheVincenzo Berghella
Sep 19, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Lu SunXiaoou Xue
Jan 11, 2021·American Journal of Obstetrics & Gynecology MFM·Enrica MastantuoniUNKNOWN Italian Preterm Birth Prevention Working Group
Feb 7, 2020·American Journal of Obstetrics and Gynecology·Agustin Conde-AgudeloKypros H Nicolaides
Apr 3, 2020·Current Vascular Pharmacology·Alfonso MateCarmen M Vázquez
Aug 4, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Alfonso MateCarmen M Vázquez

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