Omega-6 fats for the primary and secondary prevention of cardiovascular disease

The Cochrane Database of Systematic Reviews
Lee HooperKatherine Ho Deane

Abstract

Omega-6 fats are polyunsaturated fats vital for many physiological functions, but their effect on cardiovascular disease (CVD) risk is debated. To assess effects of increasing omega-6 fats (linoleic acid (LA), gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid (DGLA) and arachidonic acid (AA)) on CVD and all-cause mortality. We searched CENTRAL, MEDLINE and Embase to May 2017 and clinicaltrials.gov and the World Health Organization International Clinical Trials Registry Platform to September 2016, without language restrictions. We checked trials included in relevant systematic reviews. We included randomised controlled trials (RCTs) comparing higher versus lower omega-6 fat intake in adults with or without CVD, assessing effects over at least 12 months. We included full texts, abstracts, trials registry entries and unpublished studies. Outcomes were all-cause mortality, CVD mortality, CVD events, risk factors (blood lipids, adiposity, blood pressure), and potential adverse events. We excluded trials where we could not separate omega-6 fat effects from those of other dietary, lifestyle or medication interventions. Two authors independently screened titles/abstracts, assessed trials for inclusion, extracted data, and assesse...Continue Reading

References

Oct 8, 1977·British Medical Journal·D BatesD Weightman
Nov 18, 1978·British Medical Journal·D BatesD Weightman
Jan 1, 1978·Advances in Experimental Medicine and Biology·J M WoodhillR B Blacket
Jun 5, 1991·Journal of the National Cancer Institute·Z DjuricS Martino
May 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·G A Jamal, H Carmichael
Jan 1, 1990·Annals of the New York Academy of Sciences·R E ManselL E Hughes
Jun 1, 1989·European Heart Journal·M L BurrS Sandham
Dec 16, 1989·Lancet
Jan 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·I D FrantzE R Brewer
May 16, 1987·British Medical Journal·M B McIllmurray, W Turkie
Jan 1, 1985·The British Journal of Ophthalmology·J Howard-WilliamsT D Hockaday
Dec 14, 1968·Lancet·S Dayton, M L Pearce
Jan 4, 1969·Lancet·S Dayton, M L Pearce
Feb 28, 1970·Lancet·S Dayton, M L Pearce
Mar 1, 1974·Zeitschrift für Ernährungswissenschaft·K Bramkamp, W Wirths
Mar 31, 1973·British Medical Journal·J H MillarR H Thompson
Jan 4, 1973·The New England Journal of Medicine·R A SturdevantS Dayton
Jan 19, 1974·British Medical Journal·J A Heady
Mar 1, 1968·Circulation·I H Page, H B Brown
Nov 1, 1970·Circulation·P Leren
Apr 1, 1968·The American Journal of Clinical Nutrition·O TurpeinenP Alivirta
Mar 1, 1983·International Journal of Epidemiology·M MiettinenR Elosuo
Apr 15, 1980·Documenta Ophthalmologica. Advances in Ophthalmology·A J HoutsmullerH E Henkes
Jan 1, 1980·Nutrition and Metabolism·A J HoutsmullerH E Henkes
Jul 17, 1995·International Journal of Cancer. Journal International Du Cancer·H S BlackS Jaax
Feb 28, 1995·Statistics in Medicine·C S BerkeyG A Colditz
Aug 1, 1994·European Heart Journal·M L BurrA M Fehily
Jan 1, 1994·Advances in Experimental Medicine and Biology·Z DjuricR W Hart

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Citations

Jul 19, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Jul 19, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Jan 12, 2019·Current Cardiology Reports·Thomas F Whayne, Sibu P Saha
Mar 3, 2020·Journal of the American Heart Association·Maria Carolina BorgesUNKNOWN UCLEB Consortium**
May 20, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Aug 23, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Nov 30, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
May 10, 2019·Frontiers in Immunology·Ana María Ruiz-LeónRosa Casas
Mar 3, 2020·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Aug 6, 2020·Biomolecules·Viktoriya S ShramkoYuliya I Ragino
Dec 22, 2020·Mediators of Inflammation·Dariusz KotlegaMalgorzata Szczuko
Apr 2, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Abrar E Al-ShaerSaame Raza Shaikh

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