Omental milky spots in the local immune response in the peritoneal cavity of rats

The Anatomical Record
E Van VugtRobert H J Beelen


Milky spots have been described as reactive structures, their classification varying from inflamed or haematopoietic tissue to lymphoid organs. In this study we investigated the reactivity of the milky spots in the omentum of rats upon induction of a chronic immune response in the peritoneal cavity. At different time points after intraperitoneal administration of Bacillus Calmette-Guérin (BCG), a peritoneal lavage was made, and the omentum and the draining parathymic lymph nodes were taken out. The cellular composition of these tissues was examined on the light microscopic level, using a panel of monoclonal antibodies, and also by electron microscopy. During the first 4 months after administering BCG, the number and size of the milky spots increased enormously. Separate macrophage, T, and B cell areas were formed, but interdigitating cells and follicular dendritic cells were not observed. The number of cells in the peritoneal cavity also increased, and the cellular composition showed a strong similarity with that of the milky spots. Especially during the onset of the experiment, most bacteria were observed in the macrophages in the milky spots rather than in the draining lymph nodes. A cellular immune response was observed in t...Continue Reading


Jun 1, 1979·European Journal of Immunology·W R McMaster, A F Williams
Jan 1, 1979·Pharmacology & Therapeutics·M S Mitchell, R I Murahata
Mar 14, 1992·Lancet·W D Fraser
Feb 1, 1992·The Journal of Experimental Medicine·N Solvason, J F Kearney
Nov 9, 1991·Lancet·J W Koten, W den Otter
Jun 1, 1991·Cell and Tissue Research·M ShimotsumaK Dux
Sep 1, 1989·European Journal of Immunology·T K Van den BergC D Dijkstra
Jul 1, 1985·The Journal of Experimental Medicine·W A JefferiesA F Williams
Aug 1, 1980·European Journal of Immunology·R J BrideauA F Williams

❮ Previous
Next ❯


Sep 8, 2010·Trends in Immunology·Denise A Kaminski, Troy D Randall
Jun 27, 2014·Clinical and Experimental Immunology·R V AnanthaJ K McCormick
Jan 15, 1998·Gastroenterology·J C HallC Platell
Mar 1, 2009·Journal of Acupuncture and Meridian Studies·Byung-Cheon LeeKwang-Sup Soh
Feb 3, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiuyang LiuYan Li
Mar 18, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Danielle CollinsDes C Winter
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Hong GuoKar Neng Lai
Oct 27, 2006·Journal of the American Society of Nephrology : JASN·Mohammad ZareieJacob van den Born
Apr 24, 1999·Diseases of the Colon and Rectum·D P O'Leary
Jun 9, 2004·The British Journal of Nutrition·Christine A MattacksCaroline M Pond
Sep 10, 2019·Journal of Anatomy·Cindy G J CleypoolRonald L A W Bleys
May 25, 2001·Current Opinion in Critical Care·F Broche, J M Tellado
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas A CarlowHermann J Ziltener
Jul 3, 2018·Frontiers in Physiology·Andres Isaza-RestrepoRafael Riveros-Dueñas
Jul 14, 2007·The International Journal of Artificial Organs·G SacchiG Garosi
Jul 20, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H Chkourko GuskyI Podgorski
Dec 14, 2017·Annals of Surgical Oncology·Robin D BlokUNKNOWN Collaborative Dutch Snapshot Research Group
Sep 25, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael S BalzerNelli Shushakova
Jul 31, 1998·FEMS Immunology and Medical Microbiology·N N MiuraT Yadomae
Dec 16, 1998·Kidney International·N LameireR H Beelen
Jun 11, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Caroline M Pond

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.