Omentin protects H9c2 cells against docetaxel cardiotoxicity

PloS One
Ricardo LageIsabel Moscoso

Abstract

Association between obesity and cardiovascular diseases is well known, however increased susceptibility of obese patients to develop several cancer types is not so commonly known. Current data suggest that poorer overall survival in cancer patients might be associated to non-cancer-related causes such as higher risk of cardiotoxicity in obese patients treated with chemotherapeutic agents. Omentin, a novel adipokine decreased in obesity, is actually in the spotlight due to its favourable effects on inflammation, glucose homeostasis and cardiovascular diseases. Also, recent data showed that in vitro anthracycline-induced cardiomyocyte apoptosis is counteracted by omentin suggesting its cardioprotective role. Our aim was to evaluate omentin effects against docetaxel toxicity. Our data indicate that omentin inhibits docetaxel-induced viability loss and that increased viability is associated to decreased caspase-3 expression and cell death. Although omentin reduces NOX4 expression, it failed to reduce docetaxel-induced reactive oxygen species production. Our results indicate that omentin decreases docetaxel-induced endoplasmic reticulum stress, suggesting that cardioprotective role might be associated to ERS inhibition. These data s...Continue Reading

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Citations

Apr 27, 2021·International Journal of Radiation Biology·Camila SalataCherley B V de Andrade
Oct 14, 2021·Archives of Physiology and Biochemistry·Zoya TahergorabiMitra Moodi
Feb 3, 2022·Expert Opinion on Therapeutic Targets·Aizhen ZhaoYe Tian

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Methods Mentioned

BETA
flow cytometry
PCR
protein folding

Software Mentioned

GraphPad Prism
FACScan
CellQuestPro

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