PMID: 2496791Mar 11, 1989Paper

Omeprazole and cimetidine in the treatment of ulcers of the body of the stomach: a double blind comparative trial. Danish Omeprazole Study Group

BMJ : British Medical Journal

Abstract

To see whether omeprazole was superior to cimetidine in healing ulcers of the body of the stomach. Double blind randomised parallel group study of omeprazole versus cimetidine for six weeks with assessment of healing at end of every second week. Outpatient referrals in 11 centres in Denmark. One hundred sixty one patients who satisfied the following criteria: age 18-79; one or more ulcers of body of stomach (that is, at or above the angulus) seen endoscopically within four days before study treatment; no H2 receptor antagonists taken within previous two weeks; no history of gastric surgery and no complications needing surgery; no concurrent treatment or disease that might confound assessment; oral contraception or an intrauterine device being used by women of childbearing age. Omeprazole 30 mg daily (one capsule in the morning) or cimetidine 1 g daily (one 200 mg tablet thrice daily, two tablets at bedtime) for six weeks. Inactive capsules and tablets provided so that all patients took same number of capsules and tablets daily. Compliance monitored by pill counts. Endoscopic evidence of accelerated healing of type I gastric ulcers after four weeks of omeprazole. Pain recorded on diary cards and patients assessed after two, four...Continue Reading

References

Apr 11, 1985·The New England Journal of Medicine·K LauritsenH H Andersen
Nov 1, 1985·Digestive Diseases and Sciences·F P Brooks

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Citations

Dec 1, 1993·Digestive Diseases and Sciences·M J Collen, M J Sheridan
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·V SavarinoG Celle
Oct 4, 1990·The New England Journal of Medicine
Apr 4, 1991·The New England Journal of Medicine·P N Maton
Aug 1, 1992·American Journal of Surgery·C L ChuaC H Low
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·K Lauritsen, E Christensen
Mar 17, 2017·The Cochrane Database of Systematic Reviews·Taline A BoghossianBarbara Farrell
May 6, 1989·BMJ : British Medical Journal·V SavarinoG Celle
Jun 1, 1991·Gut·V SavarinoG Celle
Apr 1, 1990·DICP : the Annals of Pharmacotherapy·T A LampkinG E Dukes
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·W Schepp, M Classen
Jan 1, 1993·Alimentary Pharmacology & Therapeutics·J W Freston
Jun 1, 1996·Digestive Diseases and Sciences·F Di MarioS Vigneri
Mar 18, 1991·The Medical Journal of Australia·D W PiperD J Shearman

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