'Omics'-driven discoveries in prevention and treatment of type 2 diabetes

European Journal of Clinical Investigation
Anette P Gjesing, Oluf Pedersen

Abstract

Eur J Clin Invest 2012; 42 (6): 579-588 ABSTRACT: Glucose-based methods are currently gold standards for identifying individuals at risk of type 2 diabetes. Obviously, these methods only consider one of many pathologies of impaired glucose metabolism and they all suffer from a poor specificity as type 2 diabetes risk assessment tools. Recently, however, panels of multiple biomarkers reflecting several pre-diabetic pathologies have been developed. Their specificity and potentials for future risk stratification are discussed. As a multifactorial disorder type 2 diabetes calls for a multifactorial treatment approach targeting multiple but modifiable vascular risk factors. The same holds for pre-diabetic states and prevention hereof. In addition, type 2 diabetes and pre-diabetes show major heterogeneity between affected individuals in pathology, risk of organ damages, progression rate and responsiveness to treatment or prevention. Despite the heterogeneity and uniqueness of type 2 diabetes and pre-diabetes most affected individuals are currently offered interventions as if they all have the same disease or risk of disease and will respond similarly. The complex origin and course of type 2 diabetes combined with uniformity and non-s...Continue Reading

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Apr 17, 2013·Journal of Proteomics·Daniela GradinaruDenisa Margina
Jan 3, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A ZhangX Wang
Oct 28, 2019·Science Translational Medicine·Jianli YinHaifeng Ye
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May 18, 2016·Expert Review of Proteomics·Sven-Bastiaan Haange, Nico Jehmlich
Oct 12, 2012·Journal of Proteome Research·Prabhjit KaurAmrita K Cheema

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