Omics/systems biology and cancer cachexia

Seminars in Cell & Developmental Biology
Iain J GallagherKenneth Fearon

Abstract

Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology. Emergent properties are characteristic of complex systems with the result that the end result is more than the sum of its parts. Recognition of the importance of emergent properties in biology led to the concept of systems biology wherein a holistic approach is taken to the biology at hand. Systems biology approaches will therefore play an important role in work to uncover key mechanisms with therapeutic potential in cancer cachexia. The 'omics' technologies provide a global view of biological systems. Genomics, transcriptomics, proteomics, lipidomics and metabolomics approaches all have application in the study of cancer cachexia to generate systems level models of the behaviour of this syndrome. The current work reviews recent applications of these technologies to muscle atrophy in general and cancer cachexia in particular with a view to progress towards integration of these approaches to better understand the pathology and potential treatment pat...Continue Reading

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Citations

Oct 8, 2016·BMC Cancer·Laís Rosa VianaMaria Cristina Cintra Gomes-Marcondes
Mar 16, 2017·Journal of Cachexia, Sarcopenia and Muscle·H Alexander EbhardtCarsten Jacobi
Feb 24, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Brigitte TwelkmeyerOlav Rooyackers
Feb 22, 2018·Journal of Cachexia, Sarcopenia and Muscle·Mónica Patricia CalaJose Antonio Lopez-Martin
Sep 16, 2017·European Journal of Preventive Cardiology·Louise G Shewan
Jan 31, 2019·Journal of Cachexia, Sarcopenia and Muscle·Julien AniortDaniel Taillandier
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Dec 6, 2018·Journal of Hematology & Oncology·Jie Xiong, Wei-Li Zhao
Oct 15, 2019·Frontiers in Oncology·Liyuan DaiXu Zhang
Apr 2, 2020·Journal of Cachexia, Sarcopenia and Muscle·Janice MillerRichard J E Skipworth
Feb 19, 2021·Journal of Cachexia, Sarcopenia and Muscle·Sarah A PötgensLaure B Bindels
Jul 3, 2021·Metabolites·Gabriela de Matuoka E ChiocchettiMaria Cristina Cintra Gomes-Marcondes
Aug 28, 2021·International Journal of Molecular Sciences·Roberta BelliMaurizio Muscaritoli
Apr 1, 2016·Future Oncology·Gustav van NiekerkAnna-Mart Engelbrecht

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