Omission of axillary lymph node dissection in patients who underwent total mastectomy with 1 or 2 metastatic lymph nodes

Annals of Surgical Treatment and Research
Bong Kyun KimKorean Breast Cancer Society

Abstract

Sentinel lymph node biopsy (SLNB) is the standard axillary procedure in early breast cancer patients. In a randomized trial, the survival rates were not different when axillary lymph node dissection (ALND) was omitted in patients with 1 or 2 lymph node metastases who underwent breast conserving surgery. This study aimed to compare the outcomes in patients who underwent total mastectomy (TM) with 1 or 2 metastatic nodes according to the types of axillary surgery. In total, 79,058 patients registered in the Korean Breast Cancer Society database who underwent TM were included in the analysis. The inclusion criteria were history of TM and SLNB, pathologic T stage 1 or 2, clinically negative axillary lymph nodes, 1 or 2 metastatic axillary lymph nodes, no radiation therapy, and no neoadjuvant therapy. We divided the patients into the SLNB only and SLNB + ALND groups. The groups were matched by propensity scores. We retrospectively analyzed the differences in the overall survival (OS) between the 2 groups. A total of 883 patients were matched in a 1:4 ratio for the SLNB only and SLNB + ALND groups in the cohort from 1999 to 2014. There were no significant differences in OS between the 2 groups (P = 0.413). Subgroup analysis revealed ...Continue Reading

References

Dec 3, 2005·Breast Cancer Research and Treatment·V OzmenA Mudun
Feb 10, 2011·JAMA : the Journal of the American Medical Association·Armando E GiulianoMonica Morrow
Jul 14, 2011·Annals of Surgical Oncology·Benjamin T MillerTodd M Tuttle
Feb 22, 2012·The Breast : Official Journal of the European Society of Mastology·Fary KhanIshani Rajapaksa
Nov 23, 2012·The New England Journal of Medicine·Archie Bleyer, H Gilbert Welch
Mar 16, 2013·The Lancet Oncology·Viviana GalimbertiUNKNOWN International Breast Cancer Study Group Trial 23-01 investigators
Apr 26, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y BelkacemiR Bosc
Nov 20, 2013·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Catherine BulleyChee Wee Tan
Jan 15, 2015·JAMA : the Journal of the American Medical Association·Javaid IqbalSteven A Narod
Jul 10, 2017·Breast Cancer Research and Treatment·Carol A Parise, Vincent Caggiano
Apr 10, 2018·Journal of breast cancer·Sang Yull KangUNKNOWN Korean Breast Cancer Society
May 24, 2018·Archives of Plastic Surgery·Ki Yong HongUng Sik Jin
Feb 26, 2019·Breast Care·Carlos Martin LozaRcm Database Contributors

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
biopsy

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.