Omnidispersible Hedgehog Particles with Multilayer Coatings for Multiplexed Biosensing

Journal of the American Chemical Society
Douglas G MontjoyNicholas Kotov

Abstract

Hedgehog particles (HPs) replicating the spiky geometry of pollen grains revealed surprisingly high dispersion stability regardless of whether their hydrophobicity/hydrophilicity matches that of the media or not. This property designated as omnidispersibility is attributed to the drastic reduction of van der Waals interactions between particles coated with stiff nanoscale spikes as compared to particles of the same dimensions with smooth surfaces. One may hypothesize but it remains unknown, however, whether HPs modified with polymers or nanoparticles (NPs) would retain this property. Surface modifications of the spikes will expand the functionalities of HPs, making possible their utilization as omnidispersible carriers. Here, we show that HPs carrying dense conformal coatings made by layer-by-layer (LBL/LbL) assembly maintain dispersion stability in environments of extreme polarity and ionic strength. HPs, surface-modified by multilayers of polymers and gold NPs, are capable of surface-enhanced Raman scattering (SERS) and overcome the limited colloidal stability of other SERS probes. The agglomeration resilience of HPs leads to a greater than one order of magnitude increase of SERS intensity as compared to colloids with smooth ...Continue Reading

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Citations

Feb 28, 2020·Analytical and Bioanalytical Chemistry·Louis Van der MeerenAndre G Skirtach
Oct 20, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhen DuMin Zhou
Feb 20, 2021·ACS Nano·Douglas G MontjoyNicholas A Kotov
Jun 18, 2021·Advanced Materials·Xinyi LiuWanwan Li
Sep 4, 2019·ACS Nano·Judith LangerLuis M Liz-Marzán
Feb 23, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Andrea Mariño-LópezMiguel A Correa-Duarte

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