ON- and OFF-response of the photopic electroretinogram in relation to stimulus characteristics

Documenta Ophthalmologica. Advances in Ophthalmology
Maja SustarJelka Brecelj

Abstract

The aim of this study was to explore the effect of stimulus duration, stimulus intensity, stimulus wavelength and background luminance on the amplitude and waveform of the ON- (b-wave) and OFF- (d-wave) response of the photopic ERG. The following parameters were used in this study: stimulus duration from 5 to 200 ms, the flash intensities from 0.4 to 2.1 log cd s/m2, the background luminance from 20 to 50 cd/m2 and stimulus wavelengths 460, 508 and 667 nm. Prolonging the stimulus duration from 75 to 200 ms did not influence the amplitudes of a-, b- and d-waves significantly. Higher stimulus intensities (1.9 log cd s/m2) broadened the b-wave and increased variability of its implicit time. With a brighter background (50 cd/m2) the b-wave did not broaden and its optimal amplitude was preserved. Stimuli of longer wavelengths (667 nm) significantly reduced the d-wave amplitude. Our results suggest that high intensities and longer wavelengths (red) may not be suitable stimulus parameters in the routine clinical ON- and OFF-response recording.

References

Jan 1, 1979·The Journal of Physiology·R A Normann, I Perlman
Jan 1, 1992·Documenta Ophthalmologica. Advances in Ophthalmology·M Hawlina, B Konec
Oct 1, 1981·American Journal of Optometry and Physiological Optics·J W WaltersR E Manny
Aug 1, 1995·The British Journal of Ophthalmology·U KellnerM H Foerster
Jan 1, 1996·Documenta Ophthalmologica. Advances in Ophthalmology·M QuigleyJ Milot
Dec 1, 1998·Acta Anatomica·K Ruether, U Kellner
Mar 4, 2000·Japanese Journal of Ophthalmology·M KondoY Miyake
Aug 24, 2001·Documenta Ophthalmologica. Advances in Ophthalmology·P LachapelleO Dembinska
Nov 12, 2003·The British Journal of Ophthalmology·L E AllenA T Moore
Oct 1, 2004·Documenta Ophthalmologica. Advances in Ophthalmology·Michael F MarmorUNKNOWN International Society for Clinical Electrophysiology of Vision
May 26, 2005·NeuroImage·Rasmus M Birn, Peter A Bandettini

❮ Previous
Next ❯

Citations

Nov 21, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Maja SustarJelka Brecelj
Jan 27, 2011·Documenta Ophthalmologica. Advances in Ophthalmology·Folkert K HornJan Kremers
Mar 30, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·Gobinda PangeniJan Kremers
Nov 19, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Anderson R RodriguesJan Kremers
Jul 31, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·Eric VukmanicPaul DeMarco
Jun 27, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kåre-Olav StensløkkenGöran E Nilsson
Dec 25, 2012·Retina·Ajoy VincentGraham E Holder
Mar 15, 2016·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Tina I TsaiJan Kremers
Jun 24, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Maja SustarAnthony G Robson
Oct 17, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Mathias G NittmannRadouil Tzekov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.