PMID: 9181343Jan 1, 1996Paper

On- and off-responses in the photopic electroretinogram in complete-type congenital stationary night blindness

Documenta Ophthalmologica. Advances in Ophthalmology
M QuigleyJ Milot

Abstract

We examined the on- and off-responses of the photopic electroretinogram in patients with complete congenital stationary night blindness. Standard flash electroretinograms as well as those produced in a ganzfeld modified for long-duration light stimuli (500 msec) permitted the separation of on- and off-responses in four patients and four normal subjects. The amplitude and latency of the elctroretinogram on-response (a- and b-waves) and off-response (d-wave) in addition to the oscillatory potentials of the off-response in normal subjects and patients were compared. The abnormal on-response was demonstrated in all the patients, and the off-response with its oscillatory potentials were preserved. We showed that the second portion of the off-response (of inner retinal origin) is normal. If congenital stationary night blindness is a defect of depolarizing bipolar cells, these results preclude input of the depolarizing bipolar cells and support the hyperpolarizing bipolar cells as the cellular origin of the off-response electroretinogram.

References

Mar 1, 1990·Trends in Neurosciences·N W DawW J Brunken
Jan 1, 1989·The Journal of General Physiology·R A Stockton, M M Slaughter
Mar 1, 1987·Documenta Ophthalmologica. Advances in Ophthalmology·I M SiegelR E Carr
Jul 1, 1974·American Journal of Ophthalmology·D A HillE L Berson
Jun 1, 1968·Vision Research·K T Brown
Jan 1, 1969·UCLA Forum in Medical Sciences·K T Brown

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Citations

Aug 15, 2006·Documenta Ophthalmologica. Advances in Ophthalmology·Maja SustarJelka Brecelj
Nov 21, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Maja SustarJelka Brecelj
Jul 10, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Catherine BeaulieuPierre Lachapelle
Aug 17, 2010·Documenta Ophthalmologica. Advances in Ophthalmology·Marie-Lou GaronPierre Lachapelle
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Robert L ChowRoderick R McInnes
Jun 5, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·M-L GaronP Lachapelle
Jul 31, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·Eric VukmanicPaul DeMarco
Sep 11, 2012·American Journal of Ophthalmology·Pooja GodaraJoseph Carroll
Jun 13, 1998·American Journal of Human Genetics·K M BoycottN T Bech-Hansen
Mar 21, 2020·Veterinary Ophthalmology·Nathaniel Pasmanter, Simon M Petersen-Jones
Jun 24, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Maja SustarAnthony G Robson
Feb 16, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Allison L DorfmanPierre Lachapelle

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