On a 'failed' attempt to manipulate conscious perception with transcranial magnetic stimulation to prefrontal cortex

BioRxiv : the Preprint Server for Biology
Eugene RubyMegan A.K. Peters

Abstract

It has been reported that continuous theta burst transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) impairs metacognitive awareness in visual perception (Rounis et al., 2010). Bor et al. (2017) recently attempted to replicate this result. However, the authors modified the experimental design of the original study considerably, meaning that this was not strictly a replication. In some cases, the changes are a priori expected to lower the chance of obtaining positive findings. Despite these changes, the researchers in fact still found an effect similar to Rounis et al.'s, but they claimed that it was necessary to adopt certain criteria to discard ~30% of their subjects, after which a null result was reported. Using computer simulations, we evaluated whether the subject exclusion criteria Bor et al. adopted was appropriate or beneficial. We found that, contrary to their intended purpose, excluding subjects by their criteria does not actually reduce false positive rates. Taking into account both their positive result (without subject exclusion) and negative result (after exclusion) in a Bayesian framework, we further found that their results suggest a 75% or greater likelihood that TMS to DLPFC do...Continue Reading

Related Concepts

Perception
Research Personnel
Theta Rhythm
Virus Replication
Visual Perception
Research Subject
Prefrontal Cortex
Chemicals
Transcranial Magnetic Stimulation
Metacognition

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