On a possible dual role for the lateral septal area 5-HT(1A) receptor system in the regulation of water intake and urinary excretion

Behavioural Brain Research
Gabriela Maria Pavan de Arruda CamargoWilson Abrão Saad

Abstract

The 5-hydroxytryptamine (5-HT)(1A) receptor system plays a prominent role in a variety of physiological functions and behavior and regulation of this responsiveness of the receptor system has been implicated in the central regulation of water intake and urinary excretion. The lateral septal area (LSA) exhibits a high density of 5-HT(1A) receptors, as well as a subpopulation of oxytocin (OT) receptors. Here we report the effects of pMPPF (a selective 5-HT(1A) antagonist), d(CH(2))(5)[Tyr(Me)(2)Thr(4), Orn(5), Tyr(NH(2))(9)]-vasotocin (an OT antagonist), and that 5-HT(1A) receptor system is regulated as a consequence of activation of the Na(+) channel by veratridine. Cannulae were implanted into the LSA of rats to enable the introduction of the drugs. Injections of 8-OH-DPAT (a 5-HT(1A) agonist) blocked water intake and increased urinary excretion, while pMPPF or the OT antagonist injected bilaterally before 8-OH-DPAT blocked its inhibitory effect on water intake and its diuretic effect. In contrast, increases in extracellular sodium levels induced by the sodium channel modulator, veratridine, enhanced 5-HT(1A) responsiveness for water intake and reduced the diuretic effects induced by 8-OH-DPAT. These trials demonstrated that th...Continue Reading

References

Jan 1, 1992·The Journal of Physiology·D A SaintP W Gage
Aug 30, 1988·Brain Research·M RaggenbassJ J Dreifuss
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Dec 1, 1981·Acta Physiologica Scandinavica·F FyhrquistJ Linkola
Mar 1, 1995·The Journal of Endocrinology·R J WindleM L Forsling
Dec 1, 1994·Neurochemistry International·F Saudou, R Hen
Jan 1, 1996·Annual Review of Physiology·W E Crill
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P Blier, C de Montigny
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Sep 14, 1999·British Journal of Pharmacology·J R RaymondM N Garnovskaya
Nov 24, 1999·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·E Hamel
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lucia F FranchiniLaura Vivas
May 7, 2002·Nature Neuroscience·Takeshi Y HiyamaMasaharu Noda
Nov 30, 2002·European Journal of Endocrinology·Henrik JørgensenJørgen Warberg
Feb 18, 2003·Journal of Neuroendocrinology·H JørgensenJ Warberg
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Joseph G Verbalis
Apr 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Magali GrobDidier Mouginot
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takeshi Y HiyamaMasaharu Noda
Sep 27, 2005·Physiological Reviews·Werner Ulbricht
Oct 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eiji WatanabeMasaharu Noda
Jan 6, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Masaharu Noda
Jul 18, 2006·The American Journal of Medicine·Robert W Schrier
Dec 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lisandra Oliveira MargathoJose Antunes-Rodrigues
Jan 16, 2007·Regulatory Peptides·Patrícia de Souza VillaWilson Abrão Saad
Nov 6, 2007·Experimental Physiology·Joel C Geerling, Arthur D Loewy
Feb 11, 2010·Behavioural Brain Research·Gabriela Maria Pavan de Arruda CamargoWilson Abrão Saad

❮ Previous
Next ❯

Citations

Oct 9, 2013·General and Comparative Endocrinology·Yanling GongShengli Gao
Feb 20, 2008·Current Topics in Developmental Biology·Deepa Manwani, James J Bieker
Mar 19, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jon M DavisonReetesh K Pai
Apr 14, 2021·Neuroscience and Biobehavioral Reviews·Hannah S Wirtshafter, Matthew A Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.