On Application Of Langevin Dynamics In Logarithmic Potential To Model Ion Channel Gate Activity

Cellular & Molecular Biology Letters
Agata Wawrzkiewicz-JałowieckaZbigniew J Grzywna

Abstract

We model the activity of an ion channel gate by Langevin dynamics in a logarithmic potential. This approach enables one to describe the power-law dwell-time distributions of the considered system, and the long-term correlations between the durations of the subsequent channel states, or fractal scaling of statistical characteristics of the gate's movement with time. Activity of an ion channel gate is described as an overdamped motion of the reaction coordinate in a confining logarithmic potential, which ensures great flexibility of the model. Depending on the chosen parameters, it allows one to reproduce many types of gate dynamics within the family of non-Markovian, anomalous conformational diffusion processes. In this study we apply the constructed model to largeconductance voltage and Ca2+-activated potassium channels (BKCa). The interpretation of model assumptions and parameters is provided in terms of this biological system. Our results show good agreement with the experimental data.

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Citations

Jun 3, 2017·Biochimica Et Biophysica Acta. Biomembranes·Agata Wawrzkiewicz-JałowieckaZbigniew J Grzywna
Apr 24, 2019·Physical Review Letters·Erez AghionEli Barkai
Mar 5, 2020·The Journal of Physical Chemistry. B·Agata Wawrzkiewicz-JałowieckaŁukasz Machura

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