On BC1 RNA and the fragile X mental retardation protein

Proceedings of the National Academy of Sciences of the United States of America
Anna IacoangeliHenri Tiedge

Abstract

The fragile X mental retardation protein (FMRP), the functional absence of which causes fragile X syndrome, is an RNA-binding protein that has been implicated in the regulation of local protein synthesis at the synapse. The mechanism of FMRP's interaction with its target mRNAs, however, has remained controversial. In one model, it has been proposed that BC1 RNA, a small non-protein-coding RNA that localizes to synaptodendritic domains, operates as a requisite adaptor by specifically binding to both FMRP and, via direct base-pairing, to FMRP target mRNAs. Other models posit that FMRP interacts with its target mRNAs directly, i.e., in a BC1-independent manner. Here five laboratories independently set out to test the BC1-FMRP model. We report that specific BC1-FMRP interactions could be documented neither in vitro nor in vivo. Interactions between BC1 RNA and FMRP target mRNAs were determined to be of a nonspecific nature. Significantly, the association of FMRP with bona fide target mRNAs was independent of the presence of BC1 RNA in vivo. The combined experimental evidence is discordant with a proposed scenario in which BC1 RNA acts as a bridge between FMRP and its target mRNAs and rather supports a model in which BC1 RNA and FMR...Continue Reading

References

May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·I J WeilerW T Greenough
Jun 8, 2002·Annual Review of Neuroscience·William T O'Donnell, Stephen T Warren
Aug 7, 2002·Journal of Molecular Biology·Neva WestPrescott Deininger
Aug 7, 2002·Journal of Molecular Biology·Ravi MuddashettyJürgen Brosius
May 15, 2003·Biochemical and Biophysical Research Communications·Natalia DolzhanskayaRobert B Denman
Aug 29, 2003·Molecular and Cellular Biology·Boris V SkryabinJürgen Brosius
Sep 27, 2003·Biochemical and Biophysical Research Communications·Robert B Denman
Oct 23, 2003·Human Molecular Genetics·Stephanie CemanStephen T Warren
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Peter K ToddJames S Malter
Apr 21, 2004·Nucleic Acids Research·Caroline GabusJean-Luc Darlix
Aug 12, 2004·The Biochemical Journal·Cornelia BrendelStefan Kindler
Aug 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giovanni StefaniRobert B Darnell
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Edouard W KhandjianBarbara Bardoni
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Stefan KindlerHenri Tiedge
Nov 9, 2005·Neuron·Henri Tiedge
Nov 30, 2005·Methods : a Companion to Methods in Enzymology·Jernej UleRobert B Darnell
Dec 7, 2005·The Journal of Cell Biology·Huidong WangHenri Tiedge
Jan 13, 2006·Expert Reviews in Molecular Medicine·Hengjun Chao, Christopher E Walsh
Jan 28, 2006·Expert Reviews in Molecular Medicine·Sowndramalingam SankaralingamSandra T Davidge
Mar 3, 2006·Journal of Neuroscience Research·Edward M JohnsonJennifer Gordon
Apr 22, 2006·Expert Reviews in Molecular Medicine·Barbara BardoniEdouard W Khandjian
May 2, 2006·Current Opinion in Genetics & Development·Kathryn GarberStephen T Warren
Jun 17, 2006·Annual Review of Neuroscience·Xinwei CaoFred H Gage
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron W GrossmanWilliam T Greenough
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brad E Pfeiffer, Kimberly M Huber
Jun 15, 2007·RNA Biology·Timofey S RozhdestvenskyJürgen Brosius

❮ Previous
Next ❯

Citations

May 4, 2011·Cellular and Molecular Neurobiology·Kyle C WilcoxWilliam L Klein
Apr 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Claudia Bagni
May 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anna IacoangeliHenri Tiedge
Jul 26, 2008·Nucleic Acids Research·Marie-Cécile DidiotHervé Moine
Sep 9, 2011·Genome Research·Laetitia DavidovicMarc-Emmanuel Dumas
Oct 1, 2009·Physiological Reviews·Sven Loebrich, Elly Nedivi
Mar 28, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Brad E Pfeiffer, Kimberly M Huber
Apr 30, 2010·BMC Genomics·Clara Bermudez-SantanaPeter F Stadler
Apr 10, 2013·Molecular Brain·Michael S SidorovMark F Bear
Jan 27, 2009·PLoS Biology·Elias G BecharaBarbara Bardoni
Aug 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John G StrumbosLeonard K Kaczmarek
Aug 14, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun ZhongHenri Tiedge
Apr 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Farr NiereKimberly M Huber
Jul 21, 2011·Journal of Nucleic Acids·Xin Yan, Robert B Denman
Apr 10, 2012·Annual Review of Neuroscience·Asha L BhakarMark F Bear
Oct 25, 2011·Annual Review of Pathology·Michael R SantoroStephen T Warren
Dec 25, 2012·Neuroscience·S A Swanger, G J Bassell
Dec 12, 2012·Trends in Biochemical Sciences·Anna Iacoangeli, Henri Tiedge
Sep 15, 2011·Neurobiology of Learning and Memory·Sergio T Ferreira, William L Klein
Mar 23, 2010·Trends in Neurosciences·Dan Ohtan WangR Suzanne Zukin
Jan 26, 2010·Physiology & Behavior·Jhumku D Kohtz, Emily G Berghoff
Jul 2, 2008·Biochimica Et Biophysica Acta·N Ruth ZearfossSean P Ryder
Dec 24, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·J R BrouwerB A Oostra
Nov 6, 2012·Journal of Neurochemistry·Krishna H ZivrajStefan Kindler
Nov 26, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Zhi-Wei ZhuDing-Wen Wu
Sep 29, 2012·Journal of Cellular Physiology·Edward M JohnsonJennifer Gordon
Jun 1, 2013·Developmental Neurobiology·Denise CookKeith K Murai
Jun 15, 2015·European Journal of Cell Biology·Kerstin WeissGerhard Schratt
May 13, 2010·BMC Developmental Biology·Nicole A RapicavoliSeth Blackshaw
Jan 17, 2009·Neuron·Mauro Costa-MattioliNahum Sonenberg
Nov 25, 2014·Human Molecular Genetics·Leila K MyrickStephen T Warren
Apr 16, 2014·Frontiers in Cellular Neuroscience·Sabiha Abekhoukh, Barbara Bardoni
Jan 27, 2007·Molecular and Cellular Neurosciences·Francesca FerrariClaudia Bagni
Jun 29, 2016·Scientific Reports·Thomas RobeckJürgen Brosius
Nov 1, 2017·Life·Sarah J BerkemerPeter F Stadler
Feb 12, 2017·Disease Models & Mechanisms·Sabiha AbekhoukhBarbara Bardoni
Feb 23, 2020·Biomolecules·Younghoon LeeHeegwon Shin
Mar 1, 2020·The Journal of Biological Chemistry·Hao WuJason Dictenberg

❮ Previous
Next ❯

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