Apr 9, 2020

Selective control of working memory in prefrontal, parietal, and visual cortex

BioRxiv : the Preprint Server for Biology
M. F. Panichello, Timothy J Buschman


Cognitive control guides behavior by controlling what, where, and how information is represented in the brain. Previous work has shown parietal and prefrontal cortex direct attention, which controls the representation of external sensory stimuli. However, the neural mechanisms controlling the selection of representations held 'in mind', in working memory, are unknown. To address this, we trained two monkeys to switch between two tasks, requiring them to either select an item from a set of items held in working memory or attend to one stimulus from a set of visual stimuli. Simultaneous neural recordings in prefrontal, parietal, and visual cortex found prefrontal cortex played a primary role in selecting an item from working memory, representing selection before parietal and visual cortex. Surprisingly, a common population representation in prefrontal cortex encoded selection of an item in working memory and attention to an external stimulus, suggesting prefrontal cortex may act as a domain-general controller. Selection acted on memory representations in two ways. First, selection improved the accuracy of memory reports by enhancing the selected item's representation in prefrontal and parietal cortex. Second, selection transforme...Continue Reading

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Spatial Distribution
Method Development
Protein Aggregation, Pathological
Membrane Proteins

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.