On-chip graphene oxide aptasensor for multiple protein detection

Analytica Chimica Acta
Yuko UenoHiroki Hibino

Abstract

The versatility of an on-chip graphene oxide (GO) aptasensor was successfully confirmed by the detection of three different proteins, namely, thrombin (TB), prostate specific antigen (PSA), and hemagglutinin (HA), simply by changing the aptamers but with the sensor composition remaining the same. The results indicate that both DNA and RNA aptamers immobilized on the GO surface are sufficiently active to realize an on-chip aptasensor. Molecular selectivity and concentration dependence were investigated in relation to TB and PSA detection by using a dual, triple, and quintuple microchannel configuration. The multiple target detection of TB and PSA on a single chip was also demonstrated by using a 2×3 linear-array GO aptasensor. This work enables us to apply this sensor to the development of a multicomponent analysis system for a wide variety of targets by choosing appropriate aptamers.

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Citations

Jan 13, 2016·Analytica Chimica Acta·Ying WangDanke Xu
May 13, 2017·International Journal of Pharmaceutics·Amirhossein BahreyniSeyed Mohammad Taghdisi
May 28, 2017·Journal of Biomaterials Applications·Amirhossein BahreyniSeyed Mohammad Taghdisi
Nov 30, 2016·Advanced Materials·Eden Morales-NarváezArben Merkoçi
Feb 26, 2020·Micromachines·Niazul I Khan, Edward Song
Sep 12, 2015·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yuko UenoHiroki Hibino
Dec 15, 2018·Advanced Materials·Eden Morales-Narváez, Arben Merkoçi
Nov 15, 2018·Micromachines·Donny Nugraha MazaafriantoManabu Tokeshi
Dec 15, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yuko Ueno

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