On-chip high-pressure picoliter injector for pressure-driven flow through porous media

Analytical Chemistry
David S ReichmuthBrian J Kirby

Abstract

A high-pressure (> 3 MPa) on-chip injector has been developed for microchip applications including HPLC. The mechanical injector is implemented using in situ photopolymerization of fluorinated acrylates inside wet-etched silica microchips. The injector allows reproducible injections as small as 180 pL with < 250 ms duration. The injector operated robustly over 60 days and over 1000 injections. The injector is unique among polymer-based valves as it functions in aqueous, acetonitrile, and mixed buffers at high pressures without detectable leakage.

References

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Oct 17, 2002·Analytical Chemistry·Ernest F HasselbrinkJason E Rehm
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Citations

May 8, 2007·Analytical and Bioanalytical Chemistry·Steffen Ehlert, Ulrich Tallarek
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·François O LaforgeMichael V Mirkin
May 24, 2011·Se pu = Chinese journal of chromatography·Xinjue WangQun Fang
Jun 8, 2007·Journal of Forensic Sciences·Suzanne C Bell, Rebecca D Hanes
Aug 24, 2006·Electrophoresis·Kyung Won RoDaniel R Knapp
Oct 26, 2007·Lab on a Chip·Michael J Moehlenbrock, R Scott Martin
Apr 2, 2010·Lab on a Chip·Nickolay V LavrikMichael J Sepaniak
Nov 10, 2005·Electrophoresis·László Székely, András Guttman
Apr 2, 2005·Analytical Chemistry·Hideaki HisamotoShigeru Terabe
Apr 30, 2005·Analytical Chemistry·David S ReichmuthBrian J Kirby
Sep 15, 2006·Analytical Chemistry·M De PraP J Schoenmakers
Jun 15, 2006·Analytical Chemistry·Petra S DittrichAndreas Manz

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