On-chip micellar electrokinetic chromatographic separation of phenolic chemicals in waters

Journal of Chromatography. a
Shin-ichi WakidaS Takeda

Abstract

This paper describes on-chip micellar electrokinetic chromatography (MEKC) separation of bisphenol A and 3 kinds of alkylphenols, which have been recently recognized as endocrine disrupting chemicals for fish by the Japanese government, using microchip capillary electrophoresis with UV detection. We successfully obtained high-speed separation of the phenolic chemicals within 15 s as optimizing in microfluidic controls and MEKC separation conditions. We obtained fairly good linearity with correlation coefficient of over 0.98 from 0 to 50 mg/l phenolic chemicals except for 4-nonylphenol, which sample is the mixture of many geometrical isomers (r = 0.86). The values of the relative standard deviation for peak height in 50 mg/l phenolic chemicals were less than 8% except for bisphenol A (11.0%). The limits of detection obtained at a signal-to-noise ratio of 3 were from 5.6 to 20.0 mg/l. To realize on-site monitoring, we described strategy for on-chip MEKC analysis of the phenolic chemicals in waters using a portable analyzer based on microfluidic devices.

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Citations

Oct 13, 2006·Analytical and Bioanalytical Chemistry·Sebastian Götz, Uwe Karst
Oct 31, 2008·Analytical and Bioanalytical Chemistry·Hai-Fang Li, Jin-Ming Lin
Jul 16, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Melinda AndrasiAlmos Klekner
Jan 1, 2009·Journal of Environmental Sciences (China)·Shin-Ichi Wakida
Aug 6, 2009·Journal of Separation Science·Matthew J WalworthMichael J Sepaniak
Dec 7, 2007·Electrophoresis·Ewa Dabek-ZlotorzynskaMahmoud M Yassine
Feb 23, 2008·Journal of Separation Science·Fumihiko Kitagawa, Koji Otsuka
Oct 19, 2011·The Analyst·Jana C JokerstCharles S Henry
Dec 21, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hélio FaustinoAna Paula Duarte

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