On-demand fully customizable drug tablets via 3D printing technology for personalized medicine.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Yan Jie Neriah TanSiowling Soh

Abstract

Personalized medicine should ideally be prescribed to every individual because of the unique characteristics (e.g., biological, physical, and medical) of each individual. It is, however, challenging to provide personalized medicine for the mass population of specific individuals effectively and efficiently. This manuscript describes a method of fabricating fully customizable drug tablets for personalized medicine by the 3D printing technology. This method involves the versatile fabrication of the tablets via the specifically designed 3D printed molds of different shapes and sizes, and an intuitive 1-dimensional release of drug that relates the shape of the drug-containing matrix to the release profile. The customization includes all the aspects of varying dosage, duration, release profiles, and combination of multiple drugs. In particular, it has previously been technically difficult to devise a single platform that fabricates carriers that release drug with any desired type of release profiles. This method of fabricating fully customizable tablets is simple, inexpensive, and efficient. Detailed selection and investigation of the materials ensured that the tablet and the method of fabrication are safe (e.g., biocompatible, FDA-...Continue Reading

Citations

Aug 14, 2020·Polymers·Fabrizio FinaAbdul W Basit
May 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyeon Myeong JeongSoyoung Shin
Dec 1, 2020·Biosensors & Bioelectronics·Gianluca PalmaraAlessandro Chiadò
Feb 13, 2021·International Journal of Pharmaceutics·Yan Jie Neriah TanSiowling Soh
Mar 5, 2021·International Journal of Pharmaceutics·Georgios K EleftheriadisDimitrios G Fatouros
Aug 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao ZhuLiao Cui
Apr 9, 2021·Advanced Drug Delivery Reviews·Sedigheh BorandehJukka Seppälä
Apr 26, 2021·Advanced Drug Delivery Reviews·Shriya K PatelMohamed A Alhnan
Aug 15, 2021·International Journal of Pharmaceutics·Salma E El-HabashyHoda M Eltaher

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