On-demand IC351 (Cialis) enhances erectile function in patients with erectile dysfunction

International Journal of Impotence Research
Harin Padma-NathanIC351 On-Demand Dosing Study Group

Abstract

IC351 (Cialis) is a selective inhibitor of PDE5. The efficacy and safety of on-demand dosing of IC351 in men with erectile dysfunction was assessed in a multicenter, double-blind, placebo-controlled study. One hundred seventy-nine men (mean age: 56 y) were randomized to receive placebo or IC351 at doses of 2, 5, 10 or 25 mg, taken on demand over a 3-week period. The primary endpoints were change from baseline in responses to Questions 3 (Q3) and 4 (Q4) of the International Index of Erectile Function (IIEF). IC351 significantly improved IIEF Q3 scores at all doses vs placebo (P < or =0.003). IC351 also significantly improved IIEF Q4 scores in all but the 2 mg group (P < or =0.0003). No significant changes in laboratory values, ECGs, or blood pressure were observed. The most common adverse events were headache and dyspepsia. The conclusion of this study was that on-demand IC351 at doses up to 25 mg was well tolerated and significantly improved erectile function.

Citations

Oct 30, 2003·Aging Clinical and Experimental Research·Gaetano Frajese, Flavio Pozzi
Nov 8, 2005·World Journal of Urology·Alberto BrigantiFrancesco Montorsi
Mar 6, 2007·Journal of Neurology·Setsu SawaiTakamichi Hattori
Dec 4, 2003·Biochemical and Biophysical Research Communications·Javier AnguloIñigo Sáenz de Tejada
Mar 31, 2004·The Medical Clinics of North America·Allen D SeftelStanley E Althof
Jul 9, 2002·Urology·Giulia D'AmatiEmmanuele A Jannini
Jul 11, 2001·Drug Discovery Today·J Fricker
May 2, 2002·Drug Discovery Today·Joanne Clough
Sep 13, 2008·International Journal of Impotence Research·A D Seftel
Nov 13, 2008·International Journal of Impotence Research·R C Rosen, A D Seftel
Dec 31, 2010·International Journal of Impotence Research·A Martin MoralesC Turbi
Feb 14, 2006·Nature Clinical Practice. Urology·Alberto BrigantiFrancesco Montorsi
Jun 28, 2002·British Journal of Pharmacology·Doreen E CashenWilliam J Martin
Jul 1, 2005·International Journal of Impotence Research·C ZippeR Raina
Dec 22, 2006·International Journal of Impotence Research·S Doggrell
Jun 13, 2000·International Journal of Andrology·H M Tan
Oct 2, 2001·BJU International·D G Hatzichristou, E S Pescatori
Mar 20, 2002·Journal of Sex & Marital Therapy·David M Ferguson
Jul 11, 2003·The Journal of Urology·Raymond A Costabile
Apr 29, 2006·American Journal of Therapeutics·Arshag D Mooradian, Stanley G Korenman
Dec 14, 2004·Southern Medical Journal·Marie-Lorraine ChandeclercJean-Luc Schmutz
Jul 19, 2006·International Journal of Clinical Practice·M SaylanA Esen
Jul 25, 2009·International Journal of Clinical Practice·W Dinsmore
Dec 1, 2007·Clinical Interventions in Aging·Giovanni Vanni FrajeseGaetano Frajese
Aug 11, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Srdan PopovićPredrag Dordević
Sep 24, 2004·Psychosomatic Medicine·Culley C Carson
Feb 16, 2005·Expert Opinion on Pharmacotherapy·Sheila A Doggrell
Mar 15, 2005·Archives of Andrology·E S E Hafez, S D Hafez
Feb 25, 2014·European Urology·Paolo VerzeVincenzo Mirone
Jan 23, 2010·The Journal of Sexual Medicine·Ian EardleySung Won Lee
Jan 21, 2006·The Journal of Sexual Medicine·Harin Padma-NathanClaude Teloken

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