On discounting of health gains from human papillomavirus vaccination: effects of different approaches

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Tjalke A WestraMaarten J Postma

Abstract

Discounting has long been a matter of controversy in the field of health economic evaluations. How to weigh future health effects has resulted in ongoing discussions. These discussions are imminently relevant for health care interventions with current costs but future benefits. Different approaches to discount health effects have been proposed. In this study, we estimated the impact of different approaches for discounting health benefits of human papillomavirus (HPV) vaccination. An HPV model was used to estimate the impact of different discounting approaches on the present value of health effects. For the constant discount approaches, we varied the discount rate for health effects ranging from 0% to 4%. Next, the impact of relevant alternative discounting approaches was estimated, including hyperbolic, proportional, stepwise, and time-shifted discounting. The present value of health effects gained through HPV vaccination varied strongly when varying discount rates and approaches. The application of the current Dutch guidelines resulted in a present value of health effects that was eight or two times higher than that produced when using the proportional discounting approach or when using the internationally more common 4% disco...Continue Reading

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Citations

Jan 28, 2014·PharmacoEconomics·M B Y ParoutyM J Postma
Dec 21, 2012·Expert Review of Vaccines·Mark H RozenbaumMaarten J Postma
May 11, 2013·Expert Review of Vaccines·Maarten J PostmaNathalie Largeron
Aug 28, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Mehraj B Y ParoutyMaarten J Postma
Dec 22, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Katrin HaeusslerGianluca Baio
Feb 1, 2013·Human Vaccines & Immunotherapeutics·Maarten J Postma, Baudouin A Standaert
Mar 30, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Don HusereauUNKNOWN ISPOR Health Economic Evaluation Publication Guidelines-CHEERS Good Reporting Practices Task Force
Aug 14, 2020·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Klas KellerborgPieter van Baal
May 21, 2018·PharmacoEconomics·Arthur E AttemaKarl Claxton
Dec 24, 2019·Cost Effectiveness and Resource Allocation : C/E·Jürgen JohnMareike Schad
Jan 13, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Lieven AnnemansSteven Simoens

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