On incorporating osmotic prestretch/prestress in image-driven finite element simulations of cartilage

Journal of the Mechanical Behavior of Biomedical Materials
Xiaogang WangDavid M Pierce

Abstract

Medical imaging performed in vivo captures geometries under Donnan osmotic loading, even when the articulating joint is otherwise mechanically unloaded. Hence patient-specific finite element (FE) models constructed from such medical images of cartilage represent osmotically induced prestretched/prestressed states. When applying classical modeling approaches to patient-specific simulations of cartilage a theoretical inconsistency arises: the in-vivo imaged geometry (used to construct the model) is not an unloaded, stress-free reference configuration. Furthermore when fitting nonlinear constitutive models that include osmotic swelling (to obtain material parameters), if one assumes that experimental data-generated from osmotically loaded cartilage-begin from a stress-free reference configuration the fitted stress-stretch relationship (parameters) obtained will actually describe a different behavior. In this study we: (1) establish a practical computational method to include osmotically induced prestretch/prestress in image-driven simulations of cartilage; and (2) investigate the influence of considering the prestretched/prestressed state both when fitting fiber-reinforced, biphasic constitutive models of cartilage that include os...Continue Reading

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Citations

Nov 21, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Xiaogang WangDavid M Pierce

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