PMID: 7024025Jul 1, 1981Paper

On insulin secretion

Diabetologia
I B Täljedal

Abstract

Aspects of insulin secretory mechanisms and models of diabetogenic B cell damage are discussed. Measurements of fluxes of 3H-labelled triphenylmethylphosphonium ion, 86Rb+, 42K+, 22Na+, and 45Ca2+ in isolated islets indicate that the triggering of insulin release depends on alterations in the interaction of ions with the B cells. One difficulty in the detailed analysis of these alterations are uncertainties which arise when macroscopic concepts for homogenous phases are applied to microscopic and heterogenous compartments, as exemplified by the meaning of pH in insulin secretory granules and of membrane electric potential. Nonetheless, the importance of an apparent decreased K+ permeability in mediating the insulin-releasing action of glucose, and of an apparent increased Na+ permeability in mediating the potentiating action of acetylcholine is emphasized. Fluorescent probing of Ca2+ by chlorotetracycline revealed effects of glucose alone as well as glucose-dependent and atropine-sensitive effects of acetylcholine. Although acetylcholine, sulfonylureas, and certain thiol-blocking agents may stimulate insulin release by direct effects on the B cell plasma membrane, a high capacity for D-glucose transmembrane transport has probab...Continue Reading

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Citations

May 1, 1987·Diabetologia·D Pipeleers
Sep 1, 1986·Diabetologia·K G Engström, I B Täljedal
Dec 13, 2001·Dental Materials : Official Publication of the Academy of Dental Materials·Solveig Persson-Sjögren, Göran Sjögren
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M D MeglassonF M Matschinsky
Aug 1, 1987·Acta Physiologica Scandinavica·K G Engström, I B Täljedal
Oct 15, 1984·Experientia·E GylfeB Täljedal
Oct 15, 1984·Experientia·W J MalaisseA Sener
Feb 1, 1991·Biochemical Pharmacology·L BestS Tomlinson
Jan 1, 1986·Diabetes/metabolism Reviews·M D Meglasson, F M Matschinsky
Jul 1, 1982·Clinics in Endocrinology and Metabolism·C H Brogren, A Lernmark
Jan 1, 1987·Upsala Journal of Medical Sciences·A S Landström
Apr 3, 2016·Equine Veterinary Journal·M A de Laat, M N Sillence
Mar 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·E Jennische, H A Hansson
Jan 1, 1987·The American Journal of Physiology·P Rooth, I B Täljedal

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